Chavda Hitesh, Chavada Gordhan, Patel Jaimeen, Rangpadiya Kiran, Patel Chhagan
Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat 384 001, India.
Protein Pept Lett. 2014;21(11):1176-84. doi: 10.2174/0929866521666140807101402.
In this investigation a novel approach based on mucoadhesive superporous hydrogel hybrids (SPHHs) for topi- cal vaginal drug delivery for Metronidazole was tried.
SPHHs were synthesized by solution polymerization tech- nique. The synthesized SPHHs were characterized for tensile strength, swelling behavior, porosity, density, mucoadhesion time, SEM, DSC and FT-IR studies. In vitro drug release study from prepared vaginal formulation based on SPHH was performed in simulated vaginal fluid. Different mathematical models were applied to ascertain the drug release mecha- nism. SPHHs have shown good tensile strength, mucoadhesion time and drug release for 24 hour. SEM images reflected the formation of pores and interconnected capillary channels. The release kinetic of drug from the prepared system was best explained by Korsmeyer-Peppas and Higuchi models and shown anomalous transport. The proposed novel drug de- livery system based on SPHH was successfully prepared and SPHH-DDS might be promising candidate for topical vagi- nal delivery of Metronidazole.
在本研究中，尝试了一种基于粘膜粘附性超多孔水凝胶杂化物（SPHHs）的新型方法用于甲硝唑的阴道局部给药。
通过溶液聚合技术合成SPHHs。对合成的SPHHs进行拉伸强度、溶胀行为、孔隙率、密度、粘膜粘附时间、扫描电子显微镜（SEM）、差示扫描量热法（DSC）和傅里叶变换红外光谱（FT-IR）研究。基于SPHH制备的阴道制剂在模拟阴道液中进行体外药物释放研究。应用不同的数学模型确定药物释放机制。SPHHs显示出良好的拉伸强度、粘膜粘附时间以及24小时的药物释放。SEM图像反映了孔隙和相互连接的毛细管通道的形成。所制备系统中药物的释放动力学最好用Korsmeyer-Peppas模型和Higuchi模型解释，并显示出非正规转运。基于SPHH提出的新型药物递送系统成功制备，并且SPHH-DDS可能是甲硝唑阴道局部给药的有前景的候选者。
