Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Mehsana, Gujarat 384 001, India.
Biomed Res Int. 2013;2013:563651. doi: 10.1155/2013/563651. Epub 2013 Aug 4.
Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content, in vitro drug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.
生物黏附超多孔水凝胶复合（SPHC）颗粒被开发用于琥珀酸美托洛尔的肠道传递，并对其密度、孔隙率、溶胀、形态和生物黏附性进行了研究。壳聚糖和 HPMC 分别用作生物黏附性和释放阻滞剂聚合物。采用 3(2)完全析因设计来优化壳聚糖和 HPMC 的浓度。将载药的生物黏附 SPHC 颗粒填充在胶囊中，然后用醋酸纤维素邻苯二甲酸酯对胶囊进行包衣，并对其进行药物含量、体外药物释放和稳定性研究。为了确定药物释放动力学，将药物释放曲线拟合到数学模型中。该制剂在肠道中保持生物黏附性长达 8 小时，并表现出 Hixson-Crowell 释放，具有异常的非菲克扩散型药物传递。SPHC 聚合物颗粒作为生物材料载体的应用为生物黏附性药物传递系统开辟了新的视角，并可能成为其他肠道传递分子的未来平台。
