Zeng Sai-tian, Guo Liang, Liu Shi-kai, Wang Dong-hui, Xi Jie, Huang Ping, Liu Dan-tong, Gao Jie-Fan, Feng Jing, Zhang Liang
Department of Gynaecology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou 061001, China.
Department of Gynaecology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou 061001, China.
Clin Nutr. 2015 Aug;34(4):635-41. doi: 10.1016/j.clnu.2014.07.009. Epub 2014 Jul 23.
The findings of epidemiologic studies on the association between egg consumption and ovarian cancer risk remain conflicting. The aim of this meta-analysis was to investigate whether an association exists between egg intake and ovarian cancer risk in epidemiologic studies.
A literature search was carried out using PUBMED, EMBASE, and Cochrane Library Central database for all medical literature published in English-language journals up to August 2013. Before meta-analysis, between-study heterogeneity and publication bias were assessed using adequate statistical tests. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analysis were also performed.
A total of 12 eligible studies (six case-control studies and six cohort studies) were included, involving 629,453 subjects and 3728 ovarian cancer cases. We found that high egg intake (comparing the highest with the lowest category) was associated with a significant increased risk of ovarian cancer (RR = 1.21, 95% CI [1.06, 1.38]). When we examined whether the associations differed by study type, statistically significant effect of egg intake on ovarian cancer was observed among case-control studies (RR = 1.22, 95% CI [1.03, 1.43]), but not among cohort studies (RR = 1.20, 95% CI [0.97, 1.48]).
Our findings suggest that egg consumption may increase ovarian cancer risk. Additional studies, especially large prospective cohort studies, are warranted to confirm the findings.
关于蛋类摄入与卵巢癌风险之间关联的流行病学研究结果仍存在矛盾。本荟萃分析的目的是调查在流行病学研究中，蛋类摄入量与卵巢癌风险之间是否存在关联。
利用PUBMED、EMBASE和Cochrane图书馆中央数据库，对截至2013年8月发表在英文期刊上的所有医学文献进行检索。在进行荟萃分析之前，使用适当的统计检验评估研究间的异质性和发表偏倚。采用固定效应模型和随机效应模型来估计汇总相对风险（RR）及相应的95%置信区间（CI）。还进行了亚组分析和敏感性分析。
共纳入12项符合条件的研究（6项病例对照研究和6项队列研究），涉及629453名受试者和3728例卵巢癌病例。我们发现，高蛋类摄入量（将最高类别与最低类别进行比较）与卵巢癌风险显著增加相关（RR = 1.21，95%CI[1.06，1.38]）。当我们检查这种关联是否因研究类型而异时，在病例对照研究中观察到蛋类摄入量对卵巢癌有统计学显著影响（RR = 1.22，95%CI[1.03，1.43]），但在队列研究中未观察到（RR = １.20，95%CI[0.97，1.48]）。
我们的研究结果表明，食用蛋类可能会增加卵巢癌风险。需要更多的研究，尤其是大型前瞻性队列研究，来证实这些发现。
