Zhan Xin, Wang Jie, Pan Shufen, Lu Caijuan
Obstetrics and Gynecology Department, Hangzhou First People's Hospital, Hangzhou, Zhejiang 310006, PR China.
Obstetrics and Gynecology Department, The First Affiliated Hospital of Zhejiang Chinese Medical University Zhejiang Provincial Hospital of TCM, Hangzhou, Zhejiang 310016, PR China.
Oncotarget. 2017 Jun 6;8(23):37796-37806. doi: 10.18632/oncotarget.16890.
A large number of epidemiological studies have provided conflicting results about the relationship between tea consumption and ovarian cancer. This study aimed to clarify the association between tea consumption and ovarian cancer. A literature search of the MEDICINE, Scopus, PubMed, and Web of Science databases was performed in April 2016. A total of 18 (11 case-control and 7 cohort) studies, representing data for 701,857 female subjects including 8,683 ovarian cancer cases, were included in the meta-analysis. A random-effects meta-analysis was used to compute the pooled relative risks (RR), meta regression, and publication bias, and heterogeneity analyses were performed for the included trials. We found that tea consumption had a significant protective effect against ovarian cancer (relative risk [RR] = 0.86; 95% confidence interval [CI]: 0.76, 0.96). The relationship was confirmed particularly after adjusting for family history of cancer (RR = 0.85; 95% CI: 0.72, 0.97), menopause status (RR = 0.85; 95% CI: 0.72, 0.98), education (RR = 0.82; 95% CI: 0.68, 0.96), BMI (RR = 0.85; 95% CI: 0.70, 1.00) , smoking (RR = 0.83; 95% CI: 0.72, 0.93) and Jadad score of 3 (RR = 0.76; 95% CI: 0.56, 0.95) and 5 (RR = 0.74; 95% CI: 0.59, 0.89). The Begg's and Egger's tests (all P > 0.01) showed no evidence of publication bias. In conclusion, our meta-analysis showed an inverse association between tea consumption and ovarian cancer risk. High quality cohort-clinical trials should be conducted on different tea types and their relationship with ovarian cancer.
大量的流行病学研究就饮茶与卵巢癌之间的关系给出了相互矛盾的结果。本研究旨在阐明饮茶与卵巢癌之间的关联。2016年4月对MEDICINE、Scopus、PubMed和Web of Science数据库进行了文献检索。共有18项研究（11项病例对照研究和7项队列研究）纳入荟萃分析，这些研究代表了701857名女性受试者的数据，其中包括8683例卵巢癌病例。采用随机效应荟萃分析计算合并相对风险（RR）、荟萃回归和发表偏倚，并对纳入试验进行异质性分析。我们发现饮茶对卵巢癌有显著的保护作用（相对风险[RR]=0.86；95%置信区间[CI]：0.76，0.96）。在调整癌症家族史（RR=0.85；95%CI：0.72，0.97）、绝经状态（RR=0.85；95%CI：0.72，0.98）、教育程度（RR=0.82；95%CI：0.68，0.96）、体重指数（RR=0.85；95%CI：0.70，1.00）、吸烟（RR=0.83；95%CI：0.72，0.93）以及Jadad评分为3（RR=0.76；95%CI：0.56，0.95）和5（RR=0.74；95%CI：0.59，0.89）后，这种关系得到了证实。Begg检验和Egger检验（所有P>0.01）均未显示存在发表偏倚。总之，我们的荟萃分析表明饮茶与卵巢癌风险之间存在负相关。应针对不同茶类及其与卵巢癌的关系开展高质量的队列临床试验。
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