摇蚊作为过敏原：来自印度加尔各答西孟加拉邦两种摇蚊的证据。
Chironomid midges as allergens: evidence from two species from West Bengal, Kolkata, India.
作者信息
Nandi Soumi, Aditya Gautam, Chowdhury Indrani, Das Arijit, Saha Goutam K
机构信息
Department of Zoology, University of Calcutta, Kolkata, India.
出版信息
Indian J Med Res. 2014 Jun;139(6):921-6.
BACKGROUND & OBJECTIVES: Arthropods of different taxonomic identity including chironomid midges are known to induce allergic response in humans. The present study was done to access two common chironomid species Chironomus circumdatus and Polypedilum nubifer for their sensitizing potential as an allergen in atopic patients and controls.
METHODS
Following preparation of allergenic extracts of the two chironomid species separately, 198 atopic patients attending an allergy clinic and 50 age matched controls were tested along with a routine panel of allergens to assess sensitization.
RESULTS
The skin prick test (SPT) results revealed that 189 of the 198 patients (95.4%) demonstrated sensitization to both the chironomid species. Higher levels of total IgE was observed in atopic subjects than in the control group.
INTERPRETATION & CONCLUSIONS: The results suggest that the chironomid midges Chironomus circumdatus and Polypedilum nubifer can elicit sensitization in humans. A potential risk for allergic reactions by susceptible individuals exists due to these chironomid species, owing to their abundance and chances of contact with human beings. Further studies may be initiated to characterize the nature of the allergens and to assess their clinical relevance.
背景与目的
包括摇蚊在内的不同分类身份的节肢动物已知会诱发人类过敏反应。本研究旨在评估两种常见摇蚊物种，即环带摇蚊和类摇蚊作为变应原在特应性患者和对照人群中的致敏潜力。
方法
分别制备这两种摇蚊物种的变应原提取物后，对198名前往过敏诊所就诊的特应性患者和50名年龄匹配的对照者进行检测，并同时检测一组常规变应原以评估致敏情况。
结果
皮肤点刺试验（SPT）结果显示，198名患者中有189名（95.4%）对这两种摇蚊物种均呈致敏状态。特应性受试者的总IgE水平高于对照组。
解读与结论
结果表明，环带摇蚊和类摇蚊可使人类致敏。由于这些摇蚊物种数量众多且有与人类接触的机会，易感个体存在因这些摇蚊物种而发生过敏反应的潜在风险。可开展进一步研究以明确变应原的性质并评估其临床相关性。
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