Hirabayashi K, Kubo K, Yamaguchi S, Fujimoto K, Murakami G, Nasu Y
Department of Biology, Yamanashi Women's College, Kofu, Japan.
Allergy. 1997 Feb;52(2):188-95. doi: 10.1111/j.1398-9995.1997.tb00973.x.
There have been few reports on hypersensitivity to chironomid midges in bronchial asthmatic patients around the area of hypereutrophic natural lakes, which have been notorious as an environmental hazard due to the massive occurrence of adult chironomids during several periods of the year. Our study investigated IgE antibodies to chironomid midges in bronchial asthmatic patients around the Lake Suwa area in comparison with those of the Matsumoto area (control area). A total of 123 adult patients with bronchial asthma were investigated by measurement of IgE antibodies with extracts of three chironomid midges (Chironomus yoshimatsui, C. plumosus, and Tokunagayusurika akamusi), mite, and silkworm. In addition, in the allergy testing, 12 common inhalant antigens were used. Of 123 adult patients with bronchial asthma, 65 (52.8%) produced positive allergy tests. Thirty-three (50.8%) were positive to mite, 28 (43.1%) to silkworm, 11 (16.9%) to C. yoshimatsui, eight (12.3%) to C. plumosus, and three (4.6%) to T. akamusi. We compared our results with the previous reports. The number of positive tests to silkworm in the Lake Suwa area was higher than in other areas. However, C. plumosus and T. akamusi showed a lower number of positive reactions. We considered the lower positive number of C. plumosus and T. akamusi tests in the Lake Suwa area to be related to the advanced age of patients in this area. The chironomids are an important cause of asthma, together with mite and silkworm, in the Lake Suwa area, but affect old asthmatic patients less than asthmatic children.
在富营养化天然湖泊周边地区，支气管哮喘患者对摇蚊过敏的报道较少。由于成年摇蚊在一年中的几个时期大量出现，这些湖泊作为环境危害而声名狼藉。我们的研究调查了诹访湖周边地区支气管哮喘患者针对摇蚊的IgE抗体，并与松本地区（对照地区）的患者进行了比较。通过用三种摇蚊（吉松摇蚊、羽摇蚊和红线伊蚊）、螨虫和蚕的提取物测量IgE抗体，对总共123名成年支气管哮喘患者进行了调查。此外，在过敏测试中，使用了12种常见的吸入性抗原。在123名成年支气管哮喘患者中，65名（52.8%）过敏测试呈阳性。33名（50.8%）对螨虫呈阳性，28名（43.1%）对蚕呈阳性，11名（16.9%）对吉松摇蚊呈阳性，8名（12.3%）对羽摇蚊呈阳性，3名（4.6%）对红线伊蚊呈阳性。我们将我们的结果与之前的报告进行了比较。诹访湖地区对蚕的阳性测试数量高于其他地区。然而，羽摇蚊和红线伊蚊的阳性反应数量较低。我们认为诹访湖地区羽摇蚊和红线伊蚊测试阳性数量较低与该地区患者年龄较大有关。在诹访湖地区，摇蚊与螨虫和蚕一样，是哮喘的重要病因，但对老年哮喘患者的影响小于哮喘儿童。
