Kulik G I, Pel'kis F P, Korol' V I
Eksp Onkol. 1989;11(6):34-8.
It is determined that the organism may adapt in principle to alkylating antitumour preparations, to thiophosphamide in particular, being administered for a long time. The development of cell adaptation reactions in the systems of hemopoiesis and microsomal oxidation of hepatocytes is studied. An increase in the activity of enzymes of the microsomal liver oxidation system is found as accompanied by a lower concentration of 35S-thiophosphamide in the studied tissues and blood serum. The reactivity of tissue and serum SH-groups is observed to decrease with the organism adaptation to the preparation.
已确定该生物体原则上可能适应长期施用的烷基化抗肿瘤制剂，尤其是硫磷酰胺。研究了造血系统和肝细胞微粒体氧化系统中细胞适应反应的发展。发现微粒体肝氧化系统的酶活性增加，同时所研究的组织和血清中35S-硫磷酰胺的浓度降低。观察到随着生物体对该制剂的适应，组织和血清中SH基团的反应性降低。
