Kim N I, Telegin L Iu, Pevnitskiĭ L A
Biull Eksp Biol Med. 1983 Apr;95(4):79-81.
The immunodepressant action of cyclophosphamide, thiophosphamide and sarcolysine was examined in experimental primary immune response in mice of different lines immunized with sheep red blood cells. DBA/2 and C3H/Sn mice were marked by the highest sensitivity to the immunodepressant action of the alkylating agents. BALB/c mice were relatively resistant to the immunodepressant action. Possible reasons for the interspecific differences found are discussed.
在以绵羊红细胞免疫的不同品系小鼠的实验性初次免疫应答中，检测了环磷酰胺、硫磷酰胺和溶肉瘤素的免疫抑制作用。DBA/2和C3H/Sn小鼠对烷化剂的免疫抑制作用表现出最高的敏感性。BALB/c小鼠对免疫抑制作用相对具有抗性。文中讨论了所发现的种间差异的可能原因。
