人类体内肽激素IgE抗体的自然产生。

Natural occurrence of IgE antibodies to peptide hormones in man.

作者信息

Khalaf A N, Kerp L, Schliebs B, Jägle M, Petersen K G

机构信息

Department of Endocrinology, University Hospital of Internal Medicine, Freiburg, FRG.

出版信息

Eur J Clin Invest. 1989 Oct;19(5):464-5. doi: 10.1111/j.1365-2362.1989.tb00260.x.

DOI:10.1111/j.1365-2362.1989.tb00260.x

PMID:2511022

Abstract

IgE antibodies to peptide hormones or their fragments were investigated using specific radioallergosorbent tests. Ninety-six sera were obtained from otherwise healthy individuals with a positive RAST to at least one common allergen and without previous contact to exogenous hormones. Total serum IgE was normal (less than 300 ng ml-1) in 41 and elevated in 55 sera. Only one serum with normal total IgE had reagins to proinsulin. In sera with elevated total IgE positive tests (greater than 8 x background) were observed frequently: hGH 9.1%, GHRH1-44 5.5%, GHRH1-29 12.7%, erythropoietin 10.9%, human calcitonin 14.6%, salmon calcitonin 1.8%, ACTH 5.5%, insulin 14.6%, proinsulin 7.3%, insulin A chain 1.8%, insulin B chain 18.2, C-peptide 9.1%, and IGF 9.1%. The data show natural occurrence of reagins to peptide hormones in atopic persons. A risk at exposure to these peptides may exist in about 1% of the general population.

摘要

使用特异性放射变应原吸附试验研究了针对肽类激素或其片段的IgE抗体。从至少对一种常见变应原RAST呈阳性且未曾接触过外源性激素的健康个体中获取了96份血清。41份血清的总血清IgE正常（低于300 ng/ml），55份血清的总血清IgE升高。只有一份总IgE正常的血清对胰岛素原具有反应素。在总IgE升高的血清中，经常观察到阳性试验结果（大于背景值的8倍）：人生长激素9.1%、生长激素释放激素1-44 5.5%、生长激素释放激素1-29 12.7%、促红细胞生成素10.9%、人降钙素14.6%、鲑鱼降钙素1.8%、促肾上腺皮质激素5.5%、胰岛素14.6%、胰岛素原7.3%、胰岛素A链1.8%、胰岛素B链18.2%、C肽9.1%以及胰岛素样生长因子9.1%。数据表明特应性个体中天然存在针对肽类激素的反应素。普通人群中约1%的个体在接触这些肽时可能存在风险。