Nakamatsu K, Taniguchi S, Kimura G, Baba T
Department of Experimental Cell Research, Kyushu University, Fukuoka, Japan.
FEBS Lett. 1989 Nov 6;257(2):422-6. doi: 10.1016/0014-5793(89)81587-x.
Transfer of the v-fos oncogene into a rat 3Y1 cell line transformed by v-H-ras, which is tumorigenic but non-metastatic, enhanced lung metastasis, depending on the amount of fos-related transcripts. Enhancement of the metastatic potential was associated with increases in tumor growth rate i.m. of inoculated cells but not the rate of in vitro cell growth, irrespective of the addition of tissue (e.g. lung) extract to the regular medium. These results suggest that the v-fos oncogene increased the malignancy by altering biological factors of the recipient cells responsible for cell growth and/or survival rate in vivo.
将v-fos癌基因导入由v-H-ras转化的大鼠3Y1细胞系，该细胞系具有致瘤性但无转移性，其肺转移能力增强，这取决于fos相关转录本的量。转移潜能的增强与接种细胞的体内肿瘤生长速率增加有关，但与体外细胞生长速率无关，无论常规培养基中是否添加组织（如肺）提取物。这些结果表明，v-fos癌基因通过改变受体细胞在体内负责细胞生长和/或存活率的生物学因素来增加恶性程度。
