Kawano T, Taniguchi S, Nakamatsu K, Sadano H, Baba T
Department of Experimental Cell Research, Kyushu University, Fukuoka, Japan.
Biochem Biophys Res Commun. 1987 Nov 30;149(1):173-9. doi: 10.1016/0006-291x(87)91620-2.
Transfer of the v-fos oncogene into a rat cell line transformed by Rous sarcoma virus increased both the spontaneous and experimental lung-metastasis. Metastatic ability of each v-fos transferred cell line was dependent on both the manner of integration and transcriptional amount of the v-fos oncogene, but did not correlate with the growth rate in vivo. Expression of the src, myc or ras genes were not altered by transfer of the v-fos gene, except that the myc expression was enhanced in the cell line, which acquired augmentation of growth rate in vivo but not metastatic potential to the lung. Cells of the metastatic lung nodules of each cell line also possessed exogenous fos DNA and the transcripts. These results suggest that v-fos oncogene functions in the transfected cells and causes malignant progression.
将v-fos癌基因导入由劳斯肉瘤病毒转化的大鼠细胞系中，可增加自发和实验性肺转移。每个转染了v-fos的细胞系的转移能力取决于v-fos癌基因的整合方式和转录量，但与体内生长速率无关。v-fos基因的转移并未改变src、myc或ras基因的表达，只是在体内生长速率增加但无肺转移潜能的细胞系中，myc表达增强。每个细胞系的肺转移结节细胞也含有外源性fos DNA和转录本。这些结果表明，v-fos癌基因在转染细胞中发挥作用并导致恶性进展。
