Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea. ; Department of Psychiatry and Behavioral Medicines, Duke University Medical Center, Durham, NC, USA.
Psychiatry Investig. 2014 Jul;11(3):217-22. doi: 10.4306/pi.2014.11.3.217. Epub 2014 Jul 21.
The immune hypothesis of major depressive disorder (MDD) fits well with the supposed interaction between genetic and environmental factors in disorders with a complicated etiopathogenesis. It has been suggested that infectious diseases are associated with MDD in that cytokines may play a critical role as a key modulator in the transition between infection and the development of MDD. It has been also suggested that antidepressants have immunomodulatory effects on some cytokines and cytokine receptors, although the exact mechanism has not yet been fully elucidated. Among cytokines, monocyte chemoattractant protein-1 (MCP-1) is especially well known and has attracted considerable interest owing to its immunomodulatory functions. MCP-1 is expressed in highly regionalized neuronal areas in the brain, leading to kind of modulation of neuronal activity and neuroendocrine functions commonly seen in patients with MDD. Additionally, it is involved in the control of other cytokines that have been consistently proposed as associated with the development of MDD. It also has a possible role in the neurodegenerative process of a number of central nervous system (CNS) diseases. Hence, this paper draws from the perspective of immunology to offer several suggestions about the role of MPC-1 in the development of MDD.
重度抑郁症（MDD）的免疫假说与复杂发病机制疾病中遗传和环境因素的相互作用非常吻合。有人认为，传染病与 MDD 有关，因为细胞因子可能在感染和 MDD 发展之间的转变中发挥关键调节作用。也有人认为，抗抑郁药对某些细胞因子和细胞因子受体具有免疫调节作用，尽管确切机制尚未完全阐明。在细胞因子中，单核细胞趋化蛋白-1（MCP-1）特别知名，由于其免疫调节功能，引起了相当大的关注。MCP-1 在大脑中高度区域化的神经元区域表达，导致 MDD 患者常见的神经元活动和神经内分泌功能的某种调节。此外，它还参与控制其他被一致认为与 MDD 发展相关的细胞因子的调控。它在许多中枢神经系统（CNS）疾病的神经退行性过程中也可能具有作用。因此，本文从免疫学的角度出发，就 MPC-1 在 MDD 发展中的作用提出了一些建议。
