Lorkiewicz Piotr, Waszkiewicz Napoleon
Department of Psychiatry, Medical University of Bialystok, Plac Brodowicza 1, 16-070 Choroszcz, Poland.
J Clin Med. 2021 Sep 14;10(18):4142. doi: 10.3390/jcm10184142.
The COVID-19 pandemic is spreading around the world and 187 million people have already been affected. One of its after-effects is post-COVID depression, which, according to the latest data, affects up to 40% of people who have had SARS-CoV-2 infection. A very important issue for the mental health of the general population is to look for the causes of this complication and its biomarkers. This will help in faster diagnosis and effective treatment of the affected patients. In our work, we focused on the search for major depressive disorder (MDD) biomarkers, which are also present in COVID-19 patients and may influence the development of post-COVID depression. For this purpose, we searched PubMed, Scopus and Google Scholar scientific literature databases using keywords such as 'COVID-19', 'SARS-CoV-2', 'depression', 'post-COVID', 'biomarkers' and others. Among the biomarkers found, the most important that were frequently described are increased levels of interleukin 6 (IL-6), soluble interleukin 6 receptor (sIL-6R), interleukin 1 β (IL-1β), tumor necrosis factor α (TNF-α), interferon gamma (IFN-γ), interleukin 10 (IL-10), interleukin 2 (IL-2), soluble interleukin 2 receptor (sIL-2R), C-reactive protein (CRP), Monocyte Chemoattractant Protein-1 (MCP-1), serum amyloid a (SAA1) and metabolites of the kynurenine pathway, as well as decreased brain derived neurotrophic factor (BDNF) and tryptophan (TRP). The biomarkers identified by us indicate the etiopathogenesis of post-COVID depression analogous to the leading inflammatory hypothesis of MDD.
新冠疫情正在全球蔓延，已有1.87亿人受到影响。其后遗症之一是新冠后抑郁症，根据最新数据，高达40%的感染过严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的人受到影响。对于普通人群的心理健康而言，一个非常重要的问题是寻找这种并发症的病因及其生物标志物。这将有助于更快地诊断和有效治疗受影响的患者。在我们的研究中，我们专注于寻找重度抑郁症（MDD）的生物标志物，这些标志物在新冠患者中也存在，并且可能影响新冠后抑郁症的发展。为此，我们在PubMed、Scopus和谷歌学术等科学文献数据库中搜索了“新冠”“SARS-CoV-2”“抑郁症”“新冠后”“生物标志物”等关键词。在所发现的生物标志物中，最常被描述的重要标志物包括白细胞介素6（IL-6）、可溶性白细胞介素6受体（sIL-6R）、白细胞介素1β（IL-1β）、肿瘤坏死因子α（TNF-α）、干扰素γ（IFN-γ）、白细胞介素10（IL-10）、白细胞介素2（IL-2）、可溶性白细胞介素2受体（sIL-2R）、C反应蛋白（CRP）、单核细胞趋化蛋白-1（MCP-1）、血清淀粉样蛋白A（SAA1）以及犬尿氨酸途径的代谢产物，还有脑源性神经营养因子（BDNF）和色氨酸（TRP）水平降低。我们确定的这些生物标志物表明，新冠后抑郁症的病因发病机制与MDD的主要炎症假说类似。
