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复发性动静脉血栓栓塞作为急性早幼粒细胞白血病的初始表现

Recurrent arterial and venous thromboemboli as initial presentation of acute promyelocytic leukemia.

作者信息

Trottier-Tellier Felix, Durand Madeleine, Kolan Christophe, Wistaff Robert, Nguyen Paul Van, Laskine Mikhael

机构信息

Universite de Montreal, Montreal, Canada.

Department of Medicine, Hopital Hotel-Dieu, CRCHUM, Montreal, Canada.

出版信息

J Clin Med Res. 2014 Oct;6(5):388-91. doi: 10.14740/jocmr1864w. Epub 2014 Jul 28.

DOI:10.14740/jocmr1864w
PMID:25110545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4125336/
Abstract

We report a case of a 52-year-old Caucasian woman diagnosed with a synchronic arterial and venous thrombosis as an initial presentation of an acute promyelocytic leukemia (APL). After the diagnosis, the patient was treated with all trans-retinoic acid and arsenic chemotherapy concomitant to systemic anticoagulation. This treatment regimen led to a complete remission and absence of relapse of the thrombosis or APL during the follow-up. To our knowledge, this presentation is the second case in the literature. We use this opportunity to emphasize the importance of performing a complete medical evaluation in cases of unusual thromboembolic events.

摘要

我们报告了一例52岁的白种女性患者，其同步发生动静脉血栓形成，这是急性早幼粒细胞白血病（APL）的首发表现。诊断后，患者接受全反式维甲酸和砷剂化疗，并同时进行全身抗凝治疗。该治疗方案使患者完全缓解，且在随访期间血栓形成或APL均未复发。据我们所知，这种表现是文献报道中的第二例。我们借此机会强调在不寻常的血栓栓塞事件病例中进行全面医学评估的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/4b58a2e7bff7/jocmr-06-388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/2cb2b91a6be9/jocmr-06-388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/c9351095f9d1/jocmr-06-388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/4b58a2e7bff7/jocmr-06-388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/2cb2b91a6be9/jocmr-06-388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/c9351095f9d1/jocmr-06-388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f23/4125336/4b58a2e7bff7/jocmr-06-388-g003.jpg

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