Department of Food Sciences and Nutrition, Faculty of Food Sciences and Agriculture, King Saud University, Saudi Arabia. P.O. Box 2460, Riyadh 11451 Saudi Arabia.
Department of Food Sciences and Nutrition, Faculty of Food Sciences and Agriculture, King Saud University, Saudi Arabia. P.O. Box 2460, Riyadh 11451 Saudi Arabia. ; Department of Food Science and Nutrition, Faculty of Home Economics, Minufiya University, Egypt.
Nutr Res Pract. 2014 Aug;8(4):360-7. doi: 10.4162/nrp.2014.8.4.360. Epub 2014 May 15.
BACKGROUND/OBJECTIVES: The aim of this research was to study the different long term effects of consumption of dietary oil sources with varying omega-6/omega-3 (ω-6/ω-3) polyunsaturated fatty acids (PUFAs) ratios on bone marrow fatty acid level, ex vivo prostaglandin E2 (PGE2) release, and mineral content of bone in rabbits.
MATERIALS/METHODS: For this purpose, weaning and female New Zealand white rabbits were purchased and randomly divided into five groups and offered ad libitum diets containing 70 g/kg of added oil for 100 days. The dietary lipid treatments were formulated to provide the following ratios of ω-6/ω-3 fatty acids: 8.68 soy bean oil (SBO control), 21.75 sesame oil (SO), 0.39 fish oil (FO), 0.63 algae oil (DHA), and 0.68 algae oils (DHA/ARA). DHA and ARA are two types of marine microalgae of the genus Crypthecodinium cohnii.
The dietary treatments had significant effects on the bone marrow fatty acids of rabbits. Rabbits fed the FO diet, containing the highest ω-3 PUFA concentration, and those fed the SBO diet showed the highest ω-6 PUFA. On the other hand, a positive correlation was observed between Ex vivo PGE2 level and the ω-6/ω-3 dietary ratio. Significant effects of dietary treatment on femur Ca, P, Mg, and Zn contents were observed in both genders.
Findings of the current study clearly demonstrated that dietary PUFA, particularly ω-6/ω-3 and ARA/EPA ratios are important factors in determining bone marrow fatty acid profile, and this in turn determines the capacity of bone for synthesis of PGE2, thereby reducing bone resorption and improving bone mass during growth.
背景/目的：本研究旨在研究不同的长链多不饱和脂肪酸（PUFA）ω-6/ω-3 比例的食用油脂源对骨髓脂肪酸水平、前列腺素 E2（PGE2）体外释放和兔骨矿物质含量的不同长期影响。
材料/方法：为此，我们购买了断奶和雌性新西兰白兔，并将其随机分为五组，提供自由进食含 70 g/kg 添加油的饮食 100 天。饮食脂质处理旨在提供以下 ω-6/ω-3 脂肪酸比例：8.68 大豆油（SBO 对照）、21.75 芝麻油（SO）、0.39 鱼油（FO）、0.63 藻油（DHA）和 0.68 藻油（DHA/ARA）。DHA 和 ARA 是Crypthecodinium cohnii 属海洋微藻的两种类型。
饮食处理对兔子骨髓脂肪酸有显著影响。食用 FO 饮食的兔子，其ω-3 PUFA 浓度最高，而食用 SBO 饮食的兔子，其ω-6 PUFA 浓度最高。另一方面，体外 PGE2 水平与 ω-6/ω-3 饮食比例呈正相关。饮食处理对雌雄两性股骨 Ca、P、Mg 和 Zn 含量均有显著影响。
本研究结果清楚地表明，膳食 PUFA，特别是 ω-6/ω-3 和 ARA/EPA 比例，是决定骨髓脂肪酸谱的重要因素，进而决定了骨骼合成 PGE2 的能力，从而减少骨吸收并在生长过程中增加骨量。
