东京大学医院中小肺肿瘤的立体定向体部放疗。

Stereotactic body radiotherapy for small lung tumors in the University of Tokyo Hospital.

机构信息

Department of Radiology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

出版信息

Biomed Res Int. 2014;2014:136513. doi: 10.1155/2014/136513. Epub 2014 Jul 7.

Our work on stereotactic body radiation therapy (SBRT) for primary and metastatic lung tumors will be described. The eligibility criteria for SBRT, our previous SBRT method, the definition of target volume, heterogeneity correction, the position adjustment using four-dimensional cone-beam computed tomography (4D CBCT) immediately before SBRT, volumetric modulated arc therapy (VMAT) method for SBRT, verifying of tumor position within internal target volume (ITV) using in-treatment 4D-CBCT during VMAT-SBRT, shortening of treatment time using flattening-filter-free (FFF) techniques, delivery of 4D dose calculation for lung-VMAT patients using in-treatment CBCT and LINAC log data with agility multileaf collimator, and SBRT method for centrally located lung tumors in our institution will be shown. In our institution, these efforts have been made with the goal of raising the local control rate and decreasing adverse effects after SBRT.

我们将介绍立体定向体部放射治疗（SBRT）在原发性和转移性肺肿瘤中的应用。SBRT 的入选标准、我们之前的 SBRT 方法、靶区定义、不均匀性校正、SBRT 前使用四维锥形束 CT（4D CBCT）进行的位置调整、SBRT 的容积旋转调强弧形治疗（VMAT）方法、在 VMAT-SBRT 期间使用治疗中 4D-CBCT 验证肿瘤在内部靶区（ITV）内的位置、使用无均化滤过（FFF）技术缩短治疗时间、使用 LINAC 日志数据和敏捷多叶准直器对肺 VMAT 患者进行 4D 剂量计算、以及我们机构中位于中央的肺肿瘤的 SBRT 方法。在我们机构中，这些努力旨在提高 SBRT 后的局部控制率并降低不良反应。