Xu Hong, Li Haiqing, Liu Jun, Zhu Dan, Wang Zhe, Chen Anqing, Zhao Qiang
Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
PLoS One. 2014 Aug 11;9(8):e104608. doi: 10.1371/journal.pone.0104608. eCollection 2014.
A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ε2 allele (OR = 0.78, 95% CI = 0.70-0.87) and an increased frequency of the ε4 allele (OR = 1.15, 95% CI = 1.10-1.20); The results also showed a decreased susceptibility of MI in the ε2ε3 vs. ε3ε3 analysis (OR = 0.79, 95% CI = 0.68-0.90) and in the ε2 vs. ε3 analysis (OR = 0.78, 95% CI = 0.69-0.89), an increased susceptibility of MI in the ε3ε4 vs. ε3ε3 analysis (OR = 1.26, 95% CI = 1.12-1.41), in the ε4 vs. ε3 analysis (OR = 1.22, 95% CI = 1.12-1.32) and in the ε4ε4 vs. ε3ε3 analysis (OR = 1.59, 95% CI = 1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ε3 allele (OR = 0.99, 95% CI = 0.96-1.02); ε2ε2 vs. ε3ε3 analysis (OR = 0.73, 95% CI = 0.40-1.32); or ε2ε4 vs. ε3ε3 analysis (OR = 1.10, 95% CI = 0.99-1.21). Our results suggested that the ε4 allele of ApoE is a risk factor for the development of MI and the ε2 allele of ApoE is a protective factor in the development of MI.
为了阐明载脂蛋白E（ApoE）基因多态性与心肌梗死（MI）之间的关联，已经开展了多项病例对照研究；然而，结果并不一致。本荟萃分析旨在利用所有现有证据来阐明这一问题。通过在PubMed中检索获取了所有符合条件的文章。本荟萃分析共纳入33项研究，包括18752例MI病例和18963例对照。基于所有纳入研究的汇总分析表明，MI患者中ε2等位基因频率降低（比值比[OR]=0.78，95%置信区间[CI]=0.70 - 0.87），ε4等位基因频率升高（OR=1.15，95% CI=1.10 - 1.20）；结果还显示，在ε2ε3与ε3ε3分析中MI易感性降低（OR=0.79，95% CI=0.68 - 0.90），在ε2与ε3分析中也降低（OR=0.78，95% CI=0.69 - 0.89），而在ε3ε4与ε3ε3分析中MI易感性升高（OR=1.26，95% CI=1.12 - 1.41），在ε4与ε3分析中升高（OR=1.22，95% CI=1.12 - 1.32），在ε4ε4与ε3ε3分析中升高（OR=1.59，95% CI=1.15 - 2.19）。然而，对于以下遗传模型，基因多态性与MI之间无显著关联：ε3等位基因频率（OR=0.99，95% CI=0.96 - 1.02）；ε2ε2与ε3ε3分析（OR=0.73，95% CI=0.40 - 1.32）；或ε2ε4与ε3ε3分析（OR=1.10，95% CI=0.99 - 1.21）。我们的结果表明，ApoE的ε4等位基因是MI发生的危险因素，而ApoE的ε2等位基因是MI发生的保护因素。
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