胆固醇酯转运蛋白（CETP）基因的七个功能多态性与心肌梗死风险：一项荟萃分析和荟萃回归分析

Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression.

作者信息

Wang Qi, Zhou Shao-Bo, Wang Li-Jie, Lei Ming-Ming, Wang Yong, Miao Chi, Jin Yuan-Zhe

机构信息

Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.

出版信息

PLoS One. 2014 Feb 12;9(2):e88118. doi: 10.1371/journal.pone.0088118. eCollection 2014.

OBJECTIVE

This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk.

METHOD

The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software.

RESULTS

Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might increase the risk of MI. Nevertheless, no similar findings were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), and rs4783961 (G>A) polymorphisms.

CONCLUSION

The current meta-analysis suggests that CETP rs708272 (C>T) and rs1800775 (C>A) polymorphisms may contribute to MI susceptibility, especially among Caucasians. Thus, CETP rs708272 and rs1800775 polymorphisms may be promising and potential biomarkers for early diagnosis of MI.

目的

本荟萃分析旨在评估胆固醇酯转运蛋白（CETP）基因中的七个功能多态性与心肌梗死（MI）风险之间的关系。

方法

检索了PubMed、CISCOM、CINAHL、Web of Science、谷歌学术、EBSCO、Cochrane图书馆和中国生物医学文献数据库（CBM），以查找2013年3月1日前发表的相关文章，无任何语言限制。使用STATA 12.0软件进行荟萃分析。

结果

九项病例对照研究共纳入8623例MI病例和8564例健康受试者，符合纳入标准。我们的荟萃分析结果表明，CETP rs708272（C>T）多态性可能与MI风险增加相关，尤其是在白种人中。此外，我们观察到CETP rs1800775（C>A）多态性可能增加MI风险。然而，对于CETP rs5882（A>G）、rs2303790（A>G）、rs1800776（C>A）、rs12149545（G>A）和rs4783961（G>A）多态性，未发现类似结果。