Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
The Cardiovascular Center, the First Hospital of Jilin University, Changchun 130021, China.
Gene. 2018 Oct 30;675:197-207. doi: 10.1016/j.gene.2018.06.097. Epub 2018 Jul 2.
Hypertension is one of the most common chronic diseases, constituting an independent risk factor for many diseases. Our study aimed to evaluate the association between apolipoprotein E (ApoE) genetic polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Case-control studies of ApoE polymorphism and hypertension, which were included in PubMed, Embase, Web of Science, Medline, WanFang, Vip, and CNKI information databases, were selected and evaluated according to criteria of inclusion and exclusion. Eligible data were extracted and pooled, and were analyzed and assessed using Stata 12.0. Random-effect models were used when heterogeneity existed in between-study, and fixed-effect models were applied otherwise. A total of 28 studies that consisted of 5898 cases with hypertension and 7518 controls were selected. Alleles and genotypes of ApoE between cases and controls were compared. For ApoE alleles, we observed the contrast of ApoE ε2 versus ε3 allele yielded a pooled OR of 0.99 (95% CI: 0.87-1.11; P = 0.823), whereas the contrast of ε4 versus ε3 allele yielded a pooled OR of 1.95 (95% CI: 1.50-2.54; P < 0.001). For ApoE genotypes, compared with ε3/ε3 genotype, genotypes (ε2/ε2 and ε2/ε3) showed a possible association with hypertension (OR = 0.88; 95% CI: 0.79-0.99; P = 0.033), and genotypes (ε3/ε4 and ε4/ε4) had a 2.08-fold risk of developing hypertension (OR = 2.08; 95% CI: 1.58-2.74; P < 0.001). There is the association between ApoE polymorphism and hypertension: the genotypes carrying ε2 allele may be a protective factor, and the ApoE ε4 allele and the genotypes carrying ε4 allele may be risk factors for hypertension.
高血压是最常见的慢性病之一，是许多疾病的独立危险因素。本研究旨在评估载脂蛋白 E（ApoE）基因多态性与高血压的相关性，为高血压的病因学提供证据。我们选择了纳入 PubMed、Embase、Web of Science、Medline、万方、维普和中国知网信息数据库的 ApoE 多态性与高血压的病例对照研究，并根据纳入和排除标准进行评估。提取和汇总合格数据，并使用 Stata 12.0 进行分析和评估。当研究间存在异质性时使用随机效应模型，否则使用固定效应模型。共纳入 28 项研究，包括 5898 例高血压病例和 7518 例对照。比较病例组和对照组的 ApoE 等位基因和基因型。对于 ApoE 等位基因，我们观察到 ApoE ε2 与 ε3 等位基因的对比产生的合并 OR 为 0.99（95%CI：0.87-1.11；P=0.823），而 ApoE ε4 与 ε3 等位基因的对比产生的合并 OR 为 1.95（95%CI：1.50-2.54；P<0.001）。对于 ApoE 基因型，与 ε3/ε3 基因型相比，ε2/ε2 和 ε2/ε3 基因型可能与高血压相关（OR=0.88；95%CI：0.79-0.99；P=0.033），而 ε3/ε4 和 ε4/ε4 基因型患高血压的风险增加 2.08 倍（OR=2.08；95%CI：1.58-2.74；P<0.001）。ApoE 多态性与高血压之间存在关联：携带 ε2 等位基因的基因型可能是保护因素，而 ApoE ε4 等位基因和携带 ε4 等位基因的基因型可能是高血压的危险因素。
