Barranco D, Sutton L N, Florin S, Greenberg J, Sinnwell T, Ligeti L, McLaughlin A C
Neurosurgery Department, University of Pennsylvania, Philadelphia.
J Cereb Blood Flow Metab. 1989 Dec;9(6):886-91. doi: 10.1038/jcbfm.1989.122.
19F NMR was used to determine washout curves of an inert, diffusible gas (CHF3) from the cat brain. The cerebral blood flow was estimated from a bi- or tri-phasic fit to the deconvoluted wash-out curve, using the Kety-Schmidt approach. Cerebral blood flow values determined by 19F NMR show the expected responsiveness to alterations in Paco2, but are approximately 28% lower than cerebral blood flow values determined simultaneously by radioactive microsphere techniques. High concentrations of CHF3 have little effect on intracranial pressure, mean arterial blood pressure or Paco2, but cause small changes in the blood flow to certain regions of the brain. We conclude that 19F NMR techniques utilizing low concentrations of CHF3 have potential for the noninvasive measurement of cerebral blood flow.
19F核磁共振被用于测定惰性可扩散气体（三氟甲烷）从猫脑内的清除曲线。采用凯蒂-施密特方法，通过对去卷积后的清除曲线进行双相或三相拟合来估算脑血流量。19F核磁共振测定的脑血流量值显示出对动脉血二氧化碳分压变化的预期反应性，但比放射性微球技术同时测定的脑血流量值低约28%。高浓度的三氟甲烷对颅内压、平均动脉血压或动脉血二氧化碳分压影响不大，但会引起脑某些区域血流量的微小变化。我们得出结论，利用低浓度三氟甲烷的19F核磁共振技术具有无创测量脑血流量的潜力。
