Wang Wei, Chen Xiao-Dong, Bai Hong-Min, Liao Qiu-Lin, Dai Xue-Jun, Peng Da-Yun, Cao Hui-Xia
Department of Pathology, Guangzhou Liuhuaqiao Hospital, Guangzhou, China.
Neuropathology. 2015 Feb;35(1):50-5. doi: 10.1111/neup.12142. Epub 2014 Aug 11.
A 29-year-old male patient was admitted into hospital with the main complaint of progressive visual disturbance. Both CT SCAN and MRI demonstrated a cystic-solid contrast-enhancing sellar-suprasellar mass with obvious calcification. Histopathological examination of the first resected specimen showed a typical appearance of adamantinomatous craniopharyngioma. The patient received gamma knife therapy after his first operation because of partial tumor removal. He experienced two relapses in the subsequent 2 years, for which only surgical resection was performed. The later histopathology presented malignant appearance with tumor cells moderate to severe pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio, high mitotic activity (30/10 high power fields) and focal coagulative necrosis. The patient died 9 months after identification of histologic malignancy. Clinical and histopathological features, biological behavior of one case of malignant craniopharyngioma were discussed, with a brief review of the relevant literature.
一名29岁男性患者因进行性视力障碍为主诉入院。CT扫描和MRI均显示鞍区-鞍上有一个囊实性强化肿块，伴有明显钙化。首次切除标本的组织病理学检查显示为典型的造釉细胞瘤型颅咽管瘤表现。该患者首次手术后因肿瘤部分切除接受了伽玛刀治疗。在随后的2年中他经历了2次复发，仅进行了手术切除。后来的组织病理学表现为恶性外观，肿瘤细胞有中度至重度多形性、核深染、核质比增加、高有丝分裂活性（30/10高倍视野）和局灶性凝固性坏死。该患者在组织学确诊为恶性后9个月死亡。讨论了1例恶性颅咽管瘤的临床和组织病理学特征、生物学行为，并对相关文献进行了简要回顾。
