Department of Neurosurgery, Fu Xing Hospital affiliated to Capital Medical University, Beijing 100038, People's Republic of China.
J Neurooncol. 2011 Jul;103(3):719-25. doi: 10.1007/s11060-010-0407-2. Epub 2010 Sep 26.
Craniopharyngioma is considered to be a benign intracranial tumor. Malignant transformation of craniopharyngioma has rarely been described. In this article, we report a case of ameloblastic carcinoma arising from a previously benign craniopharyngioma in a 42-year-old woman. The patient was diagnosed with craniopharyngioma in August 2004 and underwent surgical resection of a typical craniopharyngioma, the pathological result was craniopharyngioma, papillary and adamantinomatous types. During the subsequent 5 years, this patient experienced two recurrences, for which surgical resections were performed without radiotherapy. The last two pathologic diagnoses were malignant craniopharyngiomas and there was more apparent sign of malignancy in the third pathologic section. The exact pathogenesis and the biological behavior of malignant change in craniopharyngioma are not yet clear. We review the relevant literature of malignant craniopharyngioma. Histopathologic, clinical and imaging features of malignant craniopharyngioma and the possible effect of radiotherapy on the carcinogenesis are discussed.
颅咽管瘤被认为是一种良性颅内肿瘤。颅咽管瘤的恶性转化很少被描述。本文报道了一例 42 岁女性，源于先前良性颅咽管瘤的造釉细胞瘤。患者于 2004 年 8 月诊断为颅咽管瘤，并接受了典型颅咽管瘤的手术切除，病理结果为颅咽管瘤，乳头和造釉细胞类型。在随后的 5 年中，该患者经历了两次复发，均未接受放疗而行手术切除。最后两次病理诊断为恶性颅咽管瘤，第三次病理切片中更明显的恶性迹象。颅咽管瘤恶性转化的确切发病机制和生物学行为尚不清楚。我们复习了恶性颅咽管瘤的相关文献。讨论了恶性颅咽管瘤的组织病理学、临床和影像学特征以及放疗对致癌作用的可能影响。
