长链脂肪酸受体GPR120在小鼠垂体前叶促性腺激素细胞中的表达。
Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland.
作者信息
Moriyama Ryutaro, Deura Chikaya, Imoto Shingo, Nose Kazuhiro, Fukushima Nobuyuki
机构信息
Laboratory of Molecular Neurobiology, Department of Life Science, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka, 577-8502, Japan,
出版信息
Histochem Cell Biol. 2015 Jan;143(1):21-7. doi: 10.1007/s00418-014-1257-3. Epub 2014 Aug 12.
G-protein-coupled receptor 120 (GPR120) has been known to be a receptor of long-chain fatty acids. Here, we investigated GPR120 expression in the mouse pituitary gland via real-time PCR, in situ hybridization, and immunohistochemistry. GPR120 mRNA was abundantly expressed in the pituitary gland of ad-lib fed animals. In situ hybridization and immunohistochemistry revealed GPR120 expression in the gonadotropes of the anterior pituitary gland, but not in thyrotropes, somatotropes, lactotropes, corticotropes, melanotropes, and the posterior pituitary gland. Furthermore, 24 h of fasting induced an increase in GPR120 mRNA expression in the pituitary gland. These results demonstrate that GPR120 in mouse pituitary gonadotropes is upregulated by fasting and that it may play a role in controlling gonadotropin secretion.
G蛋白偶联受体120（GPR120）已知是长链脂肪酸的受体。在此，我们通过实时PCR、原位杂交和免疫组织化学研究了GPR120在小鼠垂体中的表达。GPR120 mRNA在自由采食动物的垂体中大量表达。原位杂交和免疫组织化学显示，GPR120在前垂体的促性腺细胞中表达，但在促甲状腺细胞、生长激素细胞、催乳激素细胞、促肾上腺皮质激素细胞、促黑素细胞和后垂体中不表达。此外，禁食24小时可诱导垂体中GPR120 mRNA表达增加。这些结果表明，小鼠垂体促性腺细胞中的GPR120在禁食时上调，并且它可能在控制促性腺激素分泌中起作用。
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