Nagatani A, Shibata O, Haseba S, Fukuzaki M, Tomiyasu S, Tsuzaki K, Gotou Y
Masui. 1989 Oct;38(10):1312-6.
The present study was designed to investigate the effect of nitroglycerin (TNG) ointment to attenuate the cardiovascular response of hypertensive patients during emergence from anesthesia compared with the effects of TNG infusion and nifedipine instillation in the nose. In addition, plasma TNG concentration was measured in the TNG ointment group and TNG infusion group. TNG 30 mg in ointment reduced the arterial pressure during extubation without producing hypotension and tachycardia. There was no significant difference in plasma TNG concentration between TNG ointment group and TNG infusion group each receiving 0.3 micrograms.kg-1.min-1. The study suggests that TNG ointment is useful for regulation of arterial pressure in hypertensive patients during emergence from anesthesia.
本研究旨在探讨硝酸甘油（TNG）软膏与TNG静脉输注及硝苯地平滴鼻相比，在麻醉苏醒期对高血压患者心血管反应的影响。此外，还测定了TNG软膏组和TNG静脉输注组的血浆TNG浓度。30mg软膏剂TNG可降低拔管时的动脉压，且不引起低血压和心动过速。接受0.3μg·kg-1·min-1的TNG软膏组和TNG静脉输注组之间血浆TNG浓度无显著差异。该研究表明，TNG软膏可用于调控高血压患者麻醉苏醒期的动脉压。
