Saitoh K, Ikeno S, Horiguchi Y, Fukuda H, Hirabayashi Y, Mitsuhata H, Akazawa S, Kasuda H, Shimizu R
Department of Anesthesiology, Jichi Medical School, Tochigi.
Masui. 1993 Dec;42(12):1799-802.
The effect of a cardiopulmonary bypass circuit (CPB) on serum nitroglycerin (TNG) concentrations was studied in eight patients scheduled for cardiac surgery. The CPB consisted of polyvinyl chloride tubes and polypropyrene membrane oxygenator. TNG was administered intravenously at a rate of 1 microgram.kg-1.min-1 after induction of anesthesia. Blood samples were obtained from the radial artery, central vein, venous inlet of the CPB, and arterial outlet of the CPB. No significant difference in serum TNG concentration was found between the venous inlet of the CPB and arterial outlet of the CPB. Serum TNG concentration tended to increase during complete extracorporeal circulation. This suggests that the hypothermic inhibition of TNG metabolism may be greater than the adsorption of TNG by the CPB.
在八名计划进行心脏手术的患者中，研究了体外循环回路（CPB）对血清硝酸甘油（TNG）浓度的影响。CPB由聚氯乙烯管和聚丙烯膜氧合器组成。麻醉诱导后，以1微克·千克⁻¹·分钟⁻¹的速率静脉注射TNG。从桡动脉、中心静脉、CPB的静脉入口和CPB的动脉出口采集血样。CPB的静脉入口和CPB的动脉出口之间的血清TNG浓度没有显著差异。在完全体外循环期间，血清TNG浓度有升高趋势。这表明低温对TNG代谢的抑制作用可能大于CPB对TNG的吸附作用。
