Saitoh K, Ishii R, Shimizu R, Harigai H
Department of Anesthesiology, Jichi Medical School Hospital, Tochigi.
Masui. 1992 Dec;41(12):1889-93.
We investigated the effect of number of nitroglycerin (TNG) as patches, containing 5 mg of TNG per sheet, on hemodynamics in 29 adult patients undergoing elective surgery. Patients were randomly allocated to four groups according to the number of the sheets applied (0, 2, 5 and 10 sheets). Hemodynamics as well as plasma TNG concentration were measured at 4 points (just before and 30, 60 or 120 minutes after application of TNG patch) in each group (n > or = 6). Plasma TNG concentrations depended on the number of the sheets and increased until 120 min after the application. Mean arterial pressure decreased gradually and significantly after applying two sheets or more. However, no relation was observed between the plasma concentration of TNG and the decrease in mean arterial pressure. We conclude that induced hypotension can not be intensified by increasing the number of the sheets of TNG patch.
我们研究了每片含5毫克硝酸甘油（TNG）的贴片数量对29例择期手术成年患者血流动力学的影响。根据贴片应用数量（0、2、5和10片）将患者随机分为四组。在每组（n≥6）的4个时间点（应用TNG贴片前及应用后30、60或120分钟）测量血流动力学以及血浆TNG浓度。血浆TNG浓度取决于贴片数量，并在应用后120分钟内升高。应用两片或更多片后，平均动脉压逐渐且显著降低。然而，未观察到TNG血浆浓度与平均动脉压降低之间存在关联。我们得出结论，增加TNG贴片的片数并不能增强诱导性低血压。
