Department of Medicine, Queen's University, Kingston, ON, Canada.
Diabetes Metab Syndr Obes. 2014 Jul 29;7:347-55. doi: 10.2147/DMSO.S46674. eCollection 2014.
Chronic kidney disease (CKD) is defined by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative as the presence of reduced kidney function or kidney damage for a period of 3 months or greater. Obesity is considered a risk factor for CKD development, but its precise role in contributing to CKD and end stage kidney disease is not fully elucidated. In this narrative review, the objectives are to describe the pathogenesis of CKD in obesity, including the impact of altered adipokine secretion in obesity and CKD, and to provide an overview of the clinical studies assessing the risk of obesity and CKD development.
慢性肾脏病(CKD)被美国国家肾脏基金会肾脏病预后质量倡议定义为肾脏功能下降或肾脏损伤持续 3 个月或更长时间。肥胖被认为是 CKD 发展的危险因素,但它在导致 CKD 和终末期肾病中的确切作用尚未完全阐明。在这篇叙述性综述中,我们的目的是描述肥胖相关 CKD 的发病机制,包括肥胖和 CKD 中改变的脂肪因子分泌的影响,并概述评估肥胖和 CKD 发展风险的临床研究。