Xiangya School of Medicine, Central South University, Changsha, China.
Department of Pathophysiology, Sepsis Translational Medicine Key Laboratory of Hunan Province, Xiangya School of Medicine, Central South University, Changsha, 410013, China.
Obes Surg. 2022 May;32(5):1734-1740. doi: 10.1007/s11695-022-05985-2. Epub 2022 Mar 3.
Obesity is a major and independent risk factor for onset and progression of many renal diseases. Bariatric surgery (BS) improves renal function by improving obesity-related metabolic disorders. However, the procedure is also accompanied by renal risks, including acute kidney injury (AKI) and oxalate nephropathy. Here, we briefly review the history and principle of frequently applied technique for BS and summarize the comprehensive BS effect on kidney function. Importantly, we highlight the possible molecular mechanisms associated with the recovery of renal function to provide novel ideas for future studies and clinical applications.
肥胖症是许多肾脏疾病发生和进展的主要且独立的危险因素。减重手术（BS）通过改善与肥胖相关的代谢紊乱来改善肾功能。然而，该手术也伴随着肾脏风险，包括急性肾损伤（AKI）和草酸盐肾病。在这里，我们简要回顾了 BS 常用技术的历史和原理，并总结了 BS 对肾功能的综合影响。重要的是，我们强调了与肾功能恢复相关的可能分子机制，为未来的研究和临床应用提供新的思路。
