位于胃体上部的爱泼斯坦-巴尔病毒相关淋巴上皮瘤样胃癌：两例报告

Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma located on gastric high body: two case reports.

作者信息

Bai Yanfeng, Gao Qiqi, Ren Guoping, Wang Bo, Xiang Hua

机构信息

Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

出版信息

Indian J Pathol Microbiol. 2014 Jul-Sep;57(3):463-6. doi: 10.4103/0377-4929.138775.

DOI:10.4103/0377-4929.138775

PMID:25118747

Abstract

Lymphoepithelioma-like gastric carcinoma (LELGC) is a rare neoplasm of the stomach with an incidence of 1-4% of all gastric cancers. It is characterized by the presence of a lymphoid stroma with cells arranged primarily in micro alveolar, thin trabecular, and primitive tubular patterns or isolated cells. It is one of the histological patterns observed in patients with Epstein - Barr virus (EBV)-associated gastric carcinoma (EBVaGC). In situ hybridization was usually used to confirm the presence of EBV. There are two types of EBVaGC, LELGC, and ordinary type. Approximately, 15-25% of EBVaGC exhibit the LELGC pattern. Here, we described two cases of LELGC and the related literatures were reviewed as well. The two cases were submucosal mass from a 59- or 63-year-old man. We found LELGC has special clinicopathologic features and protein expression profile. This should promote us to make a true diagnosis.

摘要

淋巴上皮瘤样胃癌（LELGC）是一种罕见的胃部肿瘤，在所有胃癌中发病率为1%-4%。其特征是存在淋巴样间质，细胞主要呈微腺泡状、细小梁状和原始管状排列或呈孤立细胞状。它是在爱泼斯坦-巴尔病毒（EBV）相关胃癌（EBVaGC）患者中观察到的组织学模式之一。原位杂交通常用于确认EBV的存在。EBVaGC有两种类型，即LELGC和普通型。大约15%-25%的EBVaGC表现为LELGC模式。在此，我们描述了2例LELGC病例，并对相关文献进行了回顾。这2例均为来自一名59岁或63岁男性的黏膜下肿块。我们发现LELGC具有特殊的临床病理特征和蛋白表达谱。这应促使我们做出准确诊断。