Silwal Sajan, Rahaim Ronald J
Department of Chemistry, Oklahoma State University , 107 Physical Sciences 1, Stillwater, Oklahoma 74078, United States.
J Org Chem. 2014 Sep 5;79(17):8469-76. doi: 10.1021/jo5014417. Epub 2014 Aug 22.
A modular titanium-promoted coupling of unsymmetrical internal alkynes with Weinreb amides is described. The coupling reaction takes place at room temperature and affords E-trisubstituted enones in moderate to good yields with high levels of regioselectivity. The system shows moderate chemoselectivity.
描述了一种模块化的钛促进的不对称内炔烃与Weinreb酰胺的偶联反应。该偶联反应在室温下进行，以中等至良好的产率和高区域选择性得到E-三取代烯酮。该体系表现出中等的化学选择性。
