Chisaguano Aida Maribel, Montes Rosa, Castellote Ana Isabel, Morales Eva, Júlvez Jordi, Vioque Jesús, Sunyer Jordi, López-Sabater Maria Carmen
1] Department of Nutrition and Food Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain [2] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain.
1] Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain [2] Hospital del Mar Research Institute (IMIM), Barcelona, Spain [3] CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III (ISCIII), Spanish Government, Madrid, Spain [4] Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Pediatr Res. 2014 Nov;76(5):470-6. doi: 10.1038/pr.2014.119. Epub 2014 Aug 13.
Few studies have explored whether fetal exposure to trans fatty acids (TFAs) influences the inception of atopic diseases. The aim of this study was to investigate the relationship between the concentration of specific TFAs (elaidic, vaccenic, and rumenic acids) in maternal plasma and the risk of developing atopic manifestations in the first year of life.
A subsample from a population-based pregnancy cohort of the INMA Project was analyzed. Maternal intake of fatty acids was assessed by a food-frequency questionnaire (75.5% of the cohort). TFAs and n-3 and n-6 long-chain polyunsaturated fatty acids were measured in samples of plasmatic phospholipids at 12 wk of pregnancy. Information regarding eczema and wheeze in offspring was obtained through questionnaires at ages 6 and 14 mo.
Elaidic acid correlated negatively with n-3 long-chain polyunsaturated fatty acids (total, eicosapentaenoic acid, and docosahexaenoic acid), and rumenic acid positively with both n-3 and n-6 long-chain polyunsaturated fatty acids in maternal plasma. Neither of these two fatty acids was associated with the risk of atopic eczema or wheeze in offspring in the first year of life. However, a higher vaccenic acid level was found to be linked to a lower risk of atopic eczema.
High vaccenic acid concentrations in maternal plasma may protect offspring against atopic eczema in infancy.
很少有研究探讨胎儿暴露于反式脂肪酸（TFA）是否会影响过敏性疾病的发病。本研究的目的是调查母体血浆中特定反式脂肪酸（反油酸、vaccenic酸和瘤胃酸）的浓度与生命第一年出现过敏表现风险之间的关系。
对来自INMA项目基于人群的妊娠队列的一个子样本进行分析。通过食物频率问卷评估母体脂肪酸摄入量（队列的75.5%）。在妊娠12周时测量血浆磷脂样本中的反式脂肪酸以及n-3和n-6长链多不饱和脂肪酸。通过6个月和14个月时的问卷获取有关后代湿疹和喘息的信息。
母体血浆中，反油酸与n-3长链多不饱和脂肪酸（总量、二十碳五烯酸和二十二碳六烯酸）呈负相关，瘤胃酸与n-3和n-6长链多不饱和脂肪酸均呈正相关。这两种脂肪酸均与生命第一年后代患过敏性湿疹或喘息的风险无关。然而，发现较高的vaccenic酸水平与较低的过敏性湿疹风险相关。
母体血浆中高浓度的vaccenic酸可能会保护后代在婴儿期免受过敏性湿疹的影响。
