霍乱毒素和百日咳毒素可增强主动脉平滑肌细胞中前列环素的合成。
Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells.
作者信息
Demolle D, Boeynaems J M
机构信息
Institute of Interdisciplinary Research, School of Medicine, Université Libre de Bruxelles, Belgium.
出版信息
Br J Pharmacol. 1989 Nov;98(3):717-20. doi: 10.1111/j.1476-5381.1989.tb14597.x.
Abstract
Pretreatment of bovine aortic smooth muscle cells in culture with pertussis toxin (PT) or cholera toxin (CT) potentiated the synthesis of prostacyclin (PGI2) induced by 5-hydroxytryptamine (5-HT) and phorbol-12-myristate, 13-acetate (PMA). The production of PGI2 by explants from the bovine aortic media was also synergistically stimulated by 5-HT and CT, whereas PT was inactive. These data are consistent with the hypothesis that guanosine 5'-triphosphate binding proteins are directly involved in the control of phospholipases which release free arachidonic acid for prostaglandin synthesis.
摘要
用百日咳毒素（PT）或霍乱毒素（CT）对培养的牛主动脉平滑肌细胞进行预处理，可增强5-羟色胺（5-HT）和佛波醇-12-肉豆蔻酸酯13-乙酸酯（PMA）诱导的前列环素（PGI2）合成。5-HT和CT也协同刺激牛主动脉中膜外植体产生PGI2，而PT无此作用。这些数据与以下假设一致，即鸟苷5'-三磷酸结合蛋白直接参与磷脂酶的控制，磷脂酶释放游离花生四烯酸用于前列腺素合成。
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本文引用的文献
1
Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens.培养的主动脉平滑肌对血清促细胞分裂剂的表型依赖性反应。
J Cell Biol. 1981 May;89(2):379-83. doi: 10.1083/jcb.89.2.379.
2
Physiological concentrations of ADP stimulate the release of prostacyclin from bovine aortic endothelial cells.生理浓度的二磷酸腺苷（ADP）可刺激牛主动脉内皮细胞释放前列环素。
Prostaglandins. 1984 Apr;27(4):615-26. doi: 10.1016/0090-6980(84)90097-2.
3
Identification of a serotonin type 2 receptor linked to prostacyclin synthesis in vascular smooth muscle cells.在血管平滑肌细胞中鉴定出一种与前列环素合成相关的5-羟色胺2型受体。
Biochem Pharmacol. 1984 Feb 15;33(4):692-5. doi: 10.1016/0006-2952(84)90330-7.
4
The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.平滑肌细胞。II. 培养中平滑肌的生长及弹性纤维的形成。
J Cell Biol. 1971 Jul;50(1):172-86. doi: 10.1083/jcb.50.1.172.
5
Role of protein kinase C in the control of vascular prostacyclin: study of phorbol esters effect in bovine aortic endothelium and smooth muscle.蛋白激酶C在血管前列环素调控中的作用：佛波酯对牛主动脉内皮和平滑肌作用的研究
Prostaglandins. 1988 Feb;35(2):243-57. doi: 10.1016/0090-6980(88)90091-3.
6
Dual role of GTP-binding proteins in the control of endothelial prostacyclin.GTP结合蛋白在内皮前列环素调控中的双重作用。
Biochem Biophys Res Commun. 1987 Sep 30;147(3):1113-20. doi: 10.1016/s0006-291x(87)80185-7.
7
Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.转导蛋白的βγ亚基对牛视杆细胞外段磷脂酶A2活性的刺激作用及其α亚基对该活性的抑制作用。
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3623-7. doi: 10.1073/pnas.84.11.3623.
8
Pertussis toxin inhibits the angiotensin II and serotonin-induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta.百日咳毒素可抑制血管紧张素II和血清素诱导的大鼠主动脉培养平滑肌细胞中游离细胞质钙的升高。
FEBS Lett. 1987 Feb 9;212(1):40-4. doi: 10.1016/0014-5793(87)81552-1.
9
Stimulation of prostacyclin release from aortic smooth muscle cells by purine and pyrimidine nucleotides.嘌呤和嘧啶核苷酸对主动脉平滑肌细胞前列环素释放的刺激作用。
Eur J Pharmacol. 1988 Oct 18;155(3):339-43. doi: 10.1016/0014-2999(88)90526-2.
10
Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2.α1 - 肾上腺素能受体介导的磷酸肌醇水解及前列腺素E2在麦迪逊 - 达比犬肾细胞中的生成。磷脂酶C和磷脂酶A2可能的平行激活。
J Biol Chem. 1987 Mar 25;262(9):4200-7.
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