Li Z J, Song G F, Liu S C, Gu J Z, Yang Y X, Xiao G Q
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1989;7(3):166-9.
Wedge biopsies of liver from 155 patients with advanced schistosomiasis japonica were observed pathologically, and HBsAg and HBcAg in liver were tested with double bridge peroxidase-anti-peroxidase (PAP) method. 88 of 155 cases (56.8%) were found to be HBsAg and/or HBcAg (HBAg) positive in liver. Eosinophilic intranuclear inclusions were observed in the hepatocytes of 30 cases (19.4%), in which 18 (60%) were also HBAg positive in liver. These inclusions were considered to be the markers of several virus infections, such as cytomegalovirus, herpes simplex virus, etc. The patients with positive HBAg and/or inclusion in liver had significantly more severe pathological changes in liver parenchyma. The results indicate that in addition to hepatitis B, complication with other viral infections in liver, which produce eosinophilic intranuclear inclusion, may also aggravate the pathological changes in liver and may be one of the causes of portal cirrhosis in patients with advanced schistosomiasis japonica (Fig. 1). schistosomiasis japonica
对155例晚期日本血吸虫病患者的肝脏楔形活检组织进行了病理观察，并用双桥过氧化物酶-抗过氧化物酶（PAP）法检测肝脏中的HBsAg和HBcAg。155例中有88例（56.8%）肝脏HBsAg和/或HBcAg（HBAg）阳性。在30例（19.4%）患者的肝细胞中观察到嗜酸性核内包涵体，其中18例（60%）肝脏HBAg也呈阳性。这些包涵体被认为是几种病毒感染的标志物，如巨细胞病毒、单纯疱疹病毒等。肝脏HBAg阳性和/或有包涵体的患者肝实质病理变化明显更严重。结果表明，除乙型肝炎外，肝脏并发其他产生嗜酸性核内包涵体的病毒感染也可能加重肝脏病理变化，可能是晚期日本血吸虫病患者门脉性肝硬化的病因之一（图1）。日本血吸虫病
