Ji Yinghua, Yang Xiaoyu, Li Jinsong, Lu Zhihong, Li Xiaorui, Yu Jian, Li Na
Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University Xinxiang, 453000, China.
Department of Pathology, Xinxiang Medical University Xinxiang, 453003, China.
Int J Clin Exp Pathol. 2014 Jun 15;7(7):3694-703. eCollection 2014.
IL-22, one important inflammatory cytokine of the IL-10 family, exerts its functions via IL-22 receptor that is composed of IL-22R1 and IL-10R2 subunits. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression correlates with tumor progression and poor prognosis, little is known about the role of IL-22 in gastric cancer. In our study, we found that IL-22 stimulation promoted the migration and invasion of SGC-7901 cells. Furthermore, IL-22 increased AKT activation and MMP-9 production in a time- and dose-dependent manner, while knockdown of IL-22R1 attenuated the effect of IL-22 on gastric cancer cells. In addition, blocking of AKT activation suppressed the expression and secretion of MMP-9. Taken together, this present study suggests that IL-22 stimulation enhances the migration and invasion of gastric cancer cells by regulating IL-22R1/AKT/MMP-9 signaling axis.
白细胞介素-22（IL-22）是IL-10家族的一种重要炎性细胞因子，它通过由IL-22R1和IL-10R2亚基组成的IL-22受体发挥其功能。尽管据报道IL-22在许多癌症中表达升高，且IL-22表达增加与肿瘤进展和不良预后相关，但关于IL-22在胃癌中的作用知之甚少。在我们的研究中，我们发现IL-22刺激促进了SGC-7901细胞的迁移和侵袭。此外，IL-22以时间和剂量依赖性方式增加AKT激活和MMP-9产生，而敲低IL-22R1减弱了IL-22对胃癌细胞的作用。此外，阻断AKT激活可抑制MMP-9的表达和分泌。综上所述，本研究表明IL-22刺激通过调节IL-22R1/AKT/MMP-9信号轴增强胃癌细胞的迁移和侵袭。
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