Institute of Medical Engineering & Translational Medicine, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.
Department of Internal Medicine, Division of Hematology, The Ohio State University, 400 W. 12th Ave, Columbus, OH, 43210, USA.
Immunol Res. 2023 Apr;71(2):121-129. doi: 10.1007/s12026-022-09325-5. Epub 2022 Sep 29.
IL-22 is a type 2 receptor cytokine in IL-10 family. IL-22 is usually secreted by innate and adaptive immune cells and takes its effects on non-hematopoietic cells. Through activate STAT3 pathway, IL-22 plays an important role in infection clearance and tissue regeneration, which is critical for barrier integrate and homeostasis. Abnormal activation of IL-22 signal was observed in inflammation diseases, autoimmune diseases, and cancers. We review the recent discoveries about the mechanism and regulation of IL-22 signal pathway from the perspective of intestinal micro-environment. Diet-based IL-22 target therapeutic strategies and their potential clinical significance will also be discussed.
白细胞介素 22（IL-22）是白细胞介素 10 家族中的一种 2 型受体细胞因子。IL-22 通常由先天和适应性免疫细胞分泌，并对非造血细胞发挥作用。通过激活 STAT3 途径，IL-22 在清除感染和组织再生中发挥重要作用，这对于屏障整合和内稳态至关重要。在炎症性疾病、自身免疫性疾病和癌症中观察到 IL-22 信号的异常激活。我们从肠道微环境的角度综述了 IL-22 信号通路的机制和调控的最新发现。基于饮食的 IL-22 靶向治疗策略及其潜在的临床意义也将进行讨论。
