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Association of CETP and LIPC Gene Polymorphisms with HDL and LDL Sub-fraction Levels in a Group of Indian Subjects: A Cross-Sectional Study.印度人群中 CETP 和 LIPC 基因多态性与高密度脂蛋白和低密度脂蛋白亚组分水平的关联：一项横断面研究
Indian J Clin Biochem. 2013 Apr;28(2):116-23. doi: 10.1007/s12291-012-0259-y. Epub 2012 Sep 27.
2
Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors.胆固醇酯转移蛋白：他汀类药物、贝特类药物、烟酸和胆固醇酯转移蛋白抑制剂调脂治疗作用的核心。
Eur Heart J. 2010 Jan;31(2):149-64. doi: 10.1093/eurheartj/ehp399. Epub 2009 Oct 12.
3
CETP gene variation: relation to lipid parameters and cardiovascular risk.胆固醇酯转运蛋白基因变异：与血脂参数及心血管风险的关系
Curr Opin Lipidol. 2004 Aug;15(4):393-8. doi: 10.1097/01.mol.0000137226.54278.60.
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Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol.胆固醇酯转运蛋白抑制剂对高密度脂蛋白胆固醇的影响。
N Engl J Med. 2004 Apr 8;350(15):1505-15. doi: 10.1056/NEJMoa031766.
5
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JAMA. 2003 Oct 15;290(15):2030-40. doi: 10.1001/jama.290.15.2030.
6
Polymorphisms in the CETP gene and association with CETP mass and HDL levels.胆固醇酯转运蛋白（CETP）基因多态性及其与CETP质量和高密度脂蛋白（HDL）水平的关联。
Atherosclerosis. 2003 Apr;167(2):195-204. doi: 10.1016/s0021-9150(03)00005-4.
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Clin Chim Acta. 2002 Aug;322(1-2):85-90. doi: 10.1016/s0009-8981(02)00128-6.
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Cholesteryl ester transfer protein levels and gene deficiency in Chinese patients with cardio-cerebrovascular diseases.
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Differential effect of two common polymorphisms in the cholesteryl ester transfer protein gene on low-density lipoprotein particle size.胆固醇酯转运蛋白基因中两种常见多态性对低密度脂蛋白颗粒大小的差异影响。
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心肌梗死患者胆固醇酯转运蛋白（CETP）I405v基因型及其与血脂组分的相关性研究：一项病例对照研究

Study of Cholesteryl Ester Transfer Protein (CETP) I405v Genotype and Its Association with Lipid Fractions in Myocardial Infarction Patients: A Case Control Study.

作者信息

Zende Prakash D, Bankar Mangesh P, Momin Abdul Rahman A, Kamble Pramod S

机构信息

Assistant Professor, Department of Biochemistry, Institute of Medical sciences and Research , Mayani, Tal- Khatav, Satara, Maharashtra, India .

Professor, Department of Biochemistry, B. J. Government Medical College , Pune, Maharashtra, India .

出版信息

J Clin Diagn Res. 2014 Jun;8(6):CC01-4. doi: 10.7860/JCDR/2014/7818.4441. Epub 2014 Jun 20.

DOI:10.7860/JCDR/2014/7818.4441
PMID:25120972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4129287/
Abstract

OBJECTIVES

We determine the significant relation of HDL cholesterol and total cholesterol/HDL cholesterol between CETP I405V genotypes and activity of CETP. CETP is an essential for transfer of cholesterol ester to the liver from peripheral tissues which facilitating its transfer to TG rich VLDL. Reduction activity of CETP I405V may associate with genotypes of CETP I405V. This study is undertaken to assess the presence and impact of CETP I405V genotype in our population.

MATERIALS AND METHODS

In this study 100 acute myocardial infarction patients and 100 normal age & sex matched healthy individuals were included. Serum Lipid profile was estimated by using universal standard methods whereas CETP I405V genotype was studied by ARMS PCR.

RESULT

There is presence of CETP 405Val genotype both in patient as well as in control group. RESULTs show that HDL cholesterol (p<0.0001) and ratio of total cholesterol/HDL cholesterol are significantly (p<0.0043) associated with Val/Val genotype. In addition to that the CETP I405V genotype is associated with inhibition of CETP activity with higher HDL-C level and decreased total cholesterol/HDL cholesterol ratio.

CONCLUSION

Our results show that the CETP I405V genotypes are very much significantly determinant of HDL cholesterol in patients with CHD.

摘要

目的

我们确定CETP I405V基因型与CETP活性之间高密度脂蛋白胆固醇及总胆固醇/高密度脂蛋白胆固醇的显著关系。CETP对于胆固醇酯从外周组织向肝脏的转运至关重要，有助于其向富含甘油三酯的极低密度脂蛋白的转运。CETP I405V活性降低可能与CETP I405V的基因型有关。本研究旨在评估CETP I405V基因型在我们人群中的存在情况及其影响。

材料与方法

本研究纳入了100例急性心肌梗死患者和100例年龄及性别匹配的正常健康个体。采用通用标准方法估算血清脂质谱，而通过扩增阻滞突变系统聚合酶链反应（ARMS PCR）研究CETP I405V基因型。

结果

患者组和对照组均存在CETP 405Val基因型。结果显示，高密度脂蛋白胆固醇（p<0.0001）以及总胆固醇/高密度脂蛋白胆固醇比值与Val/Val基因型显著相关（p<0.0043）。除此之外，CETP I405V基因型与CETP活性受抑制相关，表现为高密度脂蛋白胆固醇水平升高以及总胆固醇/高密度脂蛋白胆固醇比值降低。

结论

我们的结果表明，CETP I405V基因型是冠心病患者高密度脂蛋白胆固醇的非常显著的决定因素。