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核心昼夜节律网络的观测器设计

Observer design for a core circadian rhythm network.

作者信息

Zhang Yuhuan

机构信息

School of Mathematics and Information Sciences, Henan University, Kaifeng 475004, China.

出版信息

ScientificWorldJournal. 2014;2014:476912. doi: 10.1155/2014/476912. Epub 2014 Jul 8.

DOI:10.1155/2014/476912
PMID:25121122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4121104/
Abstract

The paper investigates the observer design for a core circadian rhythm network in Drosophila and Neurospora. Based on the constructed highly nonlinear differential equation model and the recently proposed graphical approach, we design a rather simple observer for the circadian rhythm oscillator, which can well track the state of the original system for various input signals. Numerical simulations show the effectiveness of the designed observer. Potential applications of the related investigations include the real-world control and experimental design of the related biological networks.

摘要

本文研究了果蝇和脉孢菌中核心昼夜节律网络的观测器设计。基于构建的高度非线性微分方程模型和最近提出的图形方法,我们为昼夜节律振荡器设计了一个相当简单的观测器,它可以很好地跟踪各种输入信号下原系统的状态。数值模拟表明了所设计观测器的有效性。相关研究的潜在应用包括相关生物网络的实际控制和实验设计。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/ce3e42412db9/TSWJ2014-476912.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/db3b8ca42f1c/TSWJ2014-476912.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/d0f5ebd74888/TSWJ2014-476912.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/dcab1e40be1f/TSWJ2014-476912.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/cdd858b2490a/TSWJ2014-476912.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/ce3e42412db9/TSWJ2014-476912.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/db3b8ca42f1c/TSWJ2014-476912.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/d0f5ebd74888/TSWJ2014-476912.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/dcab1e40be1f/TSWJ2014-476912.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/cdd858b2490a/TSWJ2014-476912.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a2c/4121104/ce3e42412db9/TSWJ2014-476912.005.jpg

相似文献

1
Observer design for a core circadian rhythm network.核心昼夜节律网络的观测器设计
ScientificWorldJournal. 2014;2014:476912. doi: 10.1155/2014/476912. Epub 2014 Jul 8.
2
Theoretical models for circadian rhythms in Neurospora and Drosophila.粗糙脉孢菌和果蝇昼夜节律的理论模型。
C R Acad Sci III. 2000 Jan;323(1):57-67. doi: 10.1016/s0764-4469(00)00111-6.
3
Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.基于果蝇和脉孢菌转录调控的昼夜节律极限环模型。
J Biol Rhythms. 1999 Dec;14(6):433-48. doi: 10.1177/074873099129000948.
4
Circadian rhythms in microorganisms: new complexities.微生物中的昼夜节律:新的复杂性。
Annu Rev Microbiol. 2004;58:489-519. doi: 10.1146/annurev.micro.58.030603.123744.
5
Yakubovich's oscillatority of circadian oscillations models.
Math Biosci. 2008 Dec;216(2):187-91. doi: 10.1016/j.mbs.2008.10.003. Epub 2008 Oct 14.
6
Circadian rhythms: PASsing time.昼夜节律:流逝的时间。
Curr Biol. 1997 Aug 1;7(8):R474-6. doi: 10.1016/s0960-9822(06)00240-5.
7
The Neurospora circadian clock: simple or complex?粗糙脉孢菌的生物钟:简单还是复杂?
Philos Trans R Soc Lond B Biol Sci. 2001 Nov 29;356(1415):1697-709. doi: 10.1098/rstb.2001.0968.
8
Hypothesis: the central oscillator of the circadian clock is a controlled chaotic attractor.假设:生物钟的中央振荡器是一个受控混沌吸引子。
Biosystems. 1993;29(2-3):77-85. doi: 10.1016/0303-2647(93)90085-q.
9
Modeling circadian oscillations with interlocking positive and negative feedback loops.用相互关联的正反馈和负反馈回路模拟昼夜节律振荡。
J Neurosci. 2001 Sep 1;21(17):6644-56. doi: 10.1523/JNEUROSCI.21-17-06644.2001.
10
Posttranslational control of the Neurospora circadian clock.粗糙脉孢菌生物钟的翻译后调控。
Cold Spring Harb Symp Quant Biol. 2007;72:185-91. doi: 10.1101/sqb.2007.72.010.

本文引用的文献

1
Defining biological networks for noise buffering and signaling sensitivity using approximate Bayesian computation.使用近似贝叶斯计算定义用于噪声缓冲和信号敏感性的生物网络。
ScientificWorldJournal. 2014;2014:625754. doi: 10.1155/2014/625754. Epub 2014 Jun 5.
2
Identification and evolution of structurally dominant nodes in protein-protein interaction networks.蛋白质-蛋白质相互作用网络中结构主导节点的识别与演化
IEEE Trans Biomed Circuits Syst. 2014 Feb;8(1):87-97. doi: 10.1109/TBCAS.2014.2303160.
3
Observability of complex systems.复杂系统的可观测性。
Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2460-5. doi: 10.1073/pnas.1215508110. Epub 2013 Jan 28.
4
Deterministic versus stochastic models for circadian rhythms.昼夜节律的确定性模型与随机模型
J Biol Phys. 2002 Dec;28(4):637-53. doi: 10.1023/A:1021286607354.
5
Synchronization of genetic oscillators.基因振荡器的同步
Chaos. 2008 Sep;18(3):037126. doi: 10.1063/1.2978183.
6
Modelling the fission yeast cell cycle.裂殖酵母细胞周期建模。
Brief Funct Genomic Proteomic. 2004 Feb;2(4):298-307. doi: 10.1093/bfgp/2.4.298.
7
The yeast cell-cycle network is robustly designed.酵母细胞周期网络的设计十分稳健。
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4781-6. doi: 10.1073/pnas.0305937101. Epub 2004 Mar 22.
8
Mathematical model of the cell division cycle of fission yeast.裂殖酵母细胞分裂周期的数学模型。
Chaos. 2001 Mar;11(1):277-286. doi: 10.1063/1.1345725.
9
Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora.基于果蝇和脉孢菌转录调控的昼夜节律极限环模型。
J Biol Rhythms. 1999 Dec;14(6):433-48. doi: 10.1177/074873099129000948.
10
Modeling the control of DNA replication in fission yeast.裂殖酵母中DNA复制控制的建模
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9147-52. doi: 10.1073/pnas.94.17.9147.