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磷酸酶相关基因变异与冠状动脉疾病之间的关联：病例对照研究与荟萃分析。

Association between phosphatase related gene variants and coronary artery disease: case-control study and meta-analysis.

作者信息

Han Xia, Zhang Lijun, Zhang Zhiqiang, Zhang Zengtang, Wang Jianchun, Yang Jun, Niu Jiamin

机构信息

Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China.

Department of Cardiology, Shandong Provincial Hospital, Jinan 250000, China.

出版信息

Int J Mol Sci. 2014 Aug 13;15(8):14058-76. doi: 10.3390/ijms150814058.

DOI:10.3390/ijms150814058
PMID:25123136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4159839/
Abstract

Recent studies showed that the serum alkaline phosphatase is an independent predictor of the coronary artery disease (CAD). In this work, we aimed to summarize the association between three phosphatase related single nucleotide polymorphisms (rs12526453, rs11066301 and rs3828329) and the risk of CAD in Han Chinese. Our results showed that the rs3828329 of the ACP1 gene was closely related to the risk of CAD in Han Chinese (OR = 1.45, p = 0.0006). This significant association of rs3828329 with CAD was only found in the females (Additive model: OR = 1.80, p = 0.001; dominant model: OR = 1.69, p = 0.03; recessive model: OR = 1.96, p = 0.0008). Moreover, rs3828329 was likely to exert its effect in females aged 65 years and older (OR = 2.27, p = 0.001). Further meta-analyses showed that the rs12526453 of PHACTR11 gene (OR = 1.14, p < 0.0001, random-effect method) and the rs11066301 of PTPN11 gene (OR = 1.15, p < 0.0001, fixed-effects method) were associated with CAD risk in multiple populations. Our results showed that the polymorphisms rs12526453 and rs11066301 are significantly associated with the CAD risk in multiple populations. The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older.

摘要

近期研究表明，血清碱性磷酸酶是冠状动脉疾病（CAD）的独立预测指标。在本研究中，我们旨在总结三种磷酸酶相关单核苷酸多态性（rs12526453、rs11066301和rs3828329）与汉族人群CAD风险之间的关联。我们的结果显示，ACP1基因的rs3828329与汉族人群的CAD风险密切相关（OR = 1.45，p = 0.0006）。rs3828329与CAD的这种显著关联仅在女性中发现（相加模型：OR = 1.80，p = 0.001；显性模型：OR = 1.69，p = 0.03；隐性模型：OR = 1.96，p = 0.0008）。此外，rs3828329可能在65岁及以上的女性中发挥作用（OR = 2.27，p = 0.001）。进一步的荟萃分析表明，PHACTR11基因中的rs12526453（OR = 1.14，p < 0.0001，随机效应法）和PTPN11基因中的rs11066301（OR = 1.15，p < 0.0001，固定效应法）与多人群中的CAD风险相关。我们结果显示，多态性rs12526453和rs11066301与多人群中的CAD风险显著相关。ACP1基因的rs3828329也是65岁及以上汉族女性CAD的一个危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/f2005be944b5/ijms-15-14058-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/8873ded1ec24/ijms-15-14058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/9d66de4a56be/ijms-15-14058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/5829a9d4352d/ijms-15-14058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/7506236075e0/ijms-15-14058-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/f2005be944b5/ijms-15-14058-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/8873ded1ec24/ijms-15-14058-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/9d66de4a56be/ijms-15-14058-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/5829a9d4352d/ijms-15-14058-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/7506236075e0/ijms-15-14058-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9507/4159839/f2005be944b5/ijms-15-14058-g005.jpg

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