审视转化生物信息学的近期主题：电子健康记录中的大数据、药物组学和个人基因组学。
Surveying Recent Themes in Translational Bioinformatics: Big Data in EHRs, Omics for Drugs, and Personal Genomics.
作者信息
Denny J C
机构信息
Joshua C. Denny, MD, MS, 2525 West End Ave - Suite 672, Nashville, TN 37213, USA, E-mail:
出版信息
Yearb Med Inform. 2014 Aug 15;9(1):199-205. doi: 10.15265/IY-2014-0015.
Abstract
OBJECTIVE
To provide a survey of recent progress in the use of large-scale biologic data to impact clinical care, and the impact the reuse of electronic health record data has made in genomic discovery.
METHOD
Survey of key themes in translational bioinformatics, primarily from 2012 and 2013.
RESULT
This survey focuses on four major themes: the growing use of Electronic Health Records (EHRs) as a source for genomic discovery, adoption of genomics and pharmacogenomics in clinical practice, the possible use of genomic technologies for drug repurposing, and the use of personal genomics to guide care.
CONCLUSION
Reuse of abundant clinical data for research is speeding discovery, and implementation of genomic data into clinical medicine is impacting care with new classes of data rarely used previously in medicine.
摘要
目的
综述利用大规模生物数据影响临床护理的最新进展，以及电子健康记录数据的再利用在基因组发现方面所产生的影响。
方法
主要针对2012年和2013年转化生物信息学的关键主题进行综述。
结果
本综述聚焦于四个主要主题：越来越多地将电子健康记录（EHRs）用作基因组发现的来源、临床实践中基因组学和药物基因组学的应用、利用基因组技术进行药物再利用的可能性，以及利用个人基因组学指导护理。
结论
将丰富的临床数据用于研究正在加速发现进程，并且将基因组数据应用于临床医学正在以医学中以前很少使用的新型数据影响护理。
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