Coöperatie 4LifeSupport Europa u.a., 2321 JW Leiden, The Netherlands.
4MedBox, 2321 JW Leiden, The Netherlands.
Genes (Basel). 2020 Nov 30;11(12):1443. doi: 10.3390/genes11121443.
One application of personalized medicine is the tailoring of medication to the individual, so that the medication will have the highest chance of success. In order to individualize medication, one must have a complete inventory of all current pharmaceutical compounds (a detailed formulary) combined with pharmacogenetic datasets, the genetic makeup of the patient, their (medical) family history and other health-related data. For healthcare professionals to make the best use of this information, it must be visualized in a way that makes the most medically relevant data accessible for their decision-making. Similarly, to enable bioinformatics analysis of these data, it must be prepared and provided through an interface for controlled computational analysis. Due to the high degree of personal information gathered for such initiatives, privacy-sensitive implementation choices and ethical standards are paramount. The Personal Genetic Locker project provides an approach to enable the use of personal genomic data in primary care. In this paper, we provide a description of the Personal Genetic Locker project and show its utility through a use case based on open standards, which is illustrated by the 4MedBox system.
个性化医疗的一个应用是针对个体定制药物，使药物有最大的成功机会。为了实现药物的个体化，必须拥有所有当前药物化合物的完整清单（详细的药物清单），结合药物遗传学数据集、患者的基因构成、他们的（医疗）家族史和其他与健康相关的数据。为了让医疗保健专业人员能够充分利用这些信息，必须以最有利于他们决策的方式将最相关的医学数据可视化。同样，为了能够对这些数据进行生物信息学分析，必须通过接口进行准备和提供，以便进行受控的计算分析。由于此类举措收集了高度的个人信息，因此隐私敏感的实施选择和道德标准至关重要。个人基因库项目提供了一种在初级保健中使用个人基因组数据的方法。在本文中，我们描述了个人基因库项目，并通过基于开放标准的用例展示了其实用性，该用例通过 4MedBox 系统进行说明。
