Yoshida K, Kimura F, Uchida K, Kawaharajo K, Koizumi N, Nakajima S, Nagaoka K
Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd., Kawasaki-shi, Japan.
J Pharmacobiodyn. 1989 Jul;12(7):398-404. doi: 10.1248/bpb1978.12.398.
A set of 16 serotype specific monoclonal antibodies (MoAbs) against Pseudomonas aeruginosa classified by Homma were obtained by the mouse hybridoma technique. This set of MoAbs was useful for classification of their serotypes especially O-antigen groups G and M. MoAb obtained from serotype 15 of Homma's classification reacted with serotype 17 of the same classification. We also obtained two MoAbs which reacted with 7 Homma's serotypes of 6 different O-antigen groups and one MoAb which recognized all 4 Homma's serotypes of O-antigen group B. These MoAbs were also useful in mice for the preventive effect against the infections of P. aeruginosa.
通过小鼠杂交瘤技术获得了一组针对由本间分类的铜绿假单胞菌的16种血清型特异性单克隆抗体（MoAb）。这组单克隆抗体对于其血清型分类尤其是O抗原组G和M很有用。从本间分类的血清型15获得的单克隆抗体与同一分类的血清型17发生反应。我们还获得了两种与6个不同O抗原组的7种本间血清型发生反应的单克隆抗体，以及一种识别O抗原组B的所有4种本间血清型的单克隆抗体。这些单克隆抗体在小鼠中对预防铜绿假单胞菌感染也很有用。
