Matthews Lynn T, Moore Lizzie, Crankshaw Tamaryn L, Milford Cecilia, Mosery Fortunate N, Greener Ross, Psaros Christina, Safren Steven A, Bangsberg David R, Smit Jennifer A
Division of Infectious Disease and Center for Global Health, Massachusetts General Hospital, 100 Cambridge Street, 15th Floor, Boston, MA 02114, USA.
BMC Public Health. 2014 Aug 14;14:843. doi: 10.1186/1471-2458-14-843.
Implementation of safer conception strategies requires knowledge of partner HIV-serostatus. We recruited women and men in a high HIV-prevalence setting for a study to assess periconception risk behavior among individuals reporting HIV-serodiscordant partnerships. We report screening data from that study with the objective of estimating the proportion of individuals who are aware that they are in an HIV-serodiscordant relationship at the time of conception.
We screened women and men attending antenatal and antiretroviral clinics in Durban, South Africa for enrollment in a study of periconception risk behavior among individuals with serodiscordant partners. Screening questionnaires assessed for study eligibility including age 18-45 years (for women) or at least 18 years of age (for men), pregnancy in past year (women) or partner pregnancy in the past 3 years (men), HIV status of partner for recent pregnancy, participant's HIV status, and infected partner's HIV status having been known before the referent pregnancy.
Among 2620 women screened, 2344 (90%) met age and pregnancy criteria and knew who fathered the referent pregnancy. Among those women, 963 (41%) did not know the pregnancy partner's HIV serostatus at time of screening. Only 92 (4%) reported knowing of a serodiscordant partnership prior to pregnancy. Among 1166 men screened, 225 (19%) met age and pregnancy criteria. Among those men, 71 (32%) did not know the pregnancy partner's HIV status and only 30 (13%) reported knowing of a serodiscordant partnership prior to pregnancy.
In an HIV-endemic setting, awareness of partner HIV serostatus is rare. Innovative strategies to increase HIV testing and disclosure are required to facilitate HIV prevention interventions for serodiscordant couples.
实施更安全的受孕策略需要了解伴侣的艾滋病毒血清学状态。我们在艾滋病毒高流行地区招募了女性和男性参与一项研究，以评估报告为艾滋病毒血清学不一致伴侣关系的个体在受孕前后的风险行为。我们报告该研究的筛查数据，目的是估计在受孕时知晓自己处于艾滋病毒血清学不一致关系的个体比例。
我们对在南非德班产前诊所和抗逆转录病毒诊所就诊的女性和男性进行筛查，以纳入一项关于血清学不一致伴侣关系个体受孕前后风险行为的研究。筛查问卷评估研究 eligibility，包括年龄在18 - 45岁（女性）或至少18岁（男性）、过去一年怀孕（女性）或过去3年伴侣怀孕（男性）、近期怀孕时伴侣的艾滋病毒状态、参与者的艾滋病毒状态以及在参考怀孕前是否已知感染伴侣的艾滋病毒状态。
在筛查的2620名女性中，2344名（90%）符合年龄和怀孕标准且知道参考怀孕的父亲是谁。在这些女性中，963名（41%）在筛查时不知道怀孕伴侣的艾滋病毒血清学状态。只有92名（4%）报告在怀孕前知晓血清学不一致的伴侣关系。在筛查的1166名男性中，225名（19%）符合年龄和怀孕标准。在这些男性中，71名（32%）不知道怀孕伴侣的艾滋病毒状态，只有30名（13%）报告在怀孕前知晓血清学不一致的伴侣关系。
在艾滋病毒流行地区，对伴侣艾滋病毒血清学状态的知晓率很低。需要创新策略来增加艾滋病毒检测和信息披露，以促进对血清学不一致夫妇的艾滋病毒预防干预。
