Zhang Xue-Zhong, Su Ai-Ling, Hu Ming-Qiu, Zhang Xiu-Qun, Xu Yan-Li
Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China E-mail :
Asian Pac J Cancer Prev. 2014;15(15):6099-101. doi: 10.7314/apjcp.2014.15.15.6099.
To retrospectively analyze variability and clinical significance of serum ferritin levels in Chinese patients with hematologic malignancies.
Serum ferritin were measured by radioimmunoassay, using a kit produced by the Beijing Institute of Atomic Energy. Patients with hematologic malignancies, and treated in the Department of Hematology in Nanjing First Hospital and fulfilled study criteria were recruited.
Of 473 patients with hematologic malignancies, 262 patients were diagnosed with acute leukemia, 131 with lymphoma and 80 with multiple myeloma. Serum ferritin levels of newly diagnosed and recurrent patients were significantly higher than those entering complete remission stage or in the control group (p<0.001).
Serum ferritin lever in patients with hematologic malignancies at early stage and recurrent stage are significantly increased, so that detection and surveillance of changes of serum ferritin could be helpful in assessing conditions and prognosis of this patient cohort.
回顾性分析中国血液系统恶性肿瘤患者血清铁蛋白水平的变异性及其临床意义。
采用北京原子能研究所生产的试剂盒，通过放射免疫分析法测定血清铁蛋白。招募在南京第一医院血液科接受治疗且符合研究标准的血液系统恶性肿瘤患者。
473例血液系统恶性肿瘤患者中，262例诊断为急性白血病，131例为淋巴瘤，80例为多发性骨髓瘤。初诊和复发患者的血清铁蛋白水平显著高于进入完全缓解期的患者或对照组（p<0.001）。
血液系统恶性肿瘤患者在疾病早期和复发阶段血清铁蛋白水平显著升高，因此检测和监测血清铁蛋白变化有助于评估该患者群体的病情和预后。
