Metabolomic (anthropometric and biochemical) indexes and metabolic syndrome in adolescents and young adults with intellectual disabilities.

The aim of the present study was to describe the use of combination of international standardized anthropometric parameters, along with biochemical parameters (metabolomic indexes) to identify metabolic syndrome (MetS), in persons with intellectual disabilities. We conducted a cross-sectional study of 42 adolescents and young adults with intellectual disabilities (aged 13-30years) who attend special schools in Ciudad Juárez, Chihuahua, México. The study included anthropometric (using the International Society for the Advancement of Kineanthropometry recommendations) and biochemical measures, and their combinations as metabolomic-indexes, that can significantly predict MetS occurrence in this vulnerable population. Waist circumference (WC) and relaxed arm circumference, both adjusted for height, have the highest correlation with MetS (R2=0.23-0.47, p<0.01). Besides body mass index (BMI) and WC we propose other indicators such as, skinfolds, hip circumference and relaxed arm circumference, all of them adjusted by height in order to better define the presence of MetS in persons with intellectual disabilities.