微小RNA-145：一种调节多种细胞通路的强效肿瘤抑制因子。

Cui Shi-Yun, Wang Rui, Chen Long-Bang

Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China.

J Cell Mol Med. 2014 Oct;18(10):1913-26. doi: 10.1111/jcmm.12358. Epub 2014 Aug 15.

MicroRNAs are endogenous, small (18-25 nucleotides) non-coding RNAs, which regulate genes expression by directly binding to the 3'-untranslated regions of the target messenger RNAs. Emerging evidence shows that alteration of microRNAs is involved in cancer development. MicroRNA-145 is commonly down-regulated in many types of cancer, regulating various cellular processes, such as the cell cycle, proliferation, apoptosis and invasion, by targeting multiple oncogenes. This review aims to summarize the recent published literature on the role of microRNA-145 in regulating tumourigenesis and progression, and explore its potential for cancer diagnosis, prognosis and treatment.

微小RNA是内源性的小（18 - 25个核苷酸）非编码RNA，其通过直接结合靶信使RNA的3'非翻译区来调节基因表达。新出现的证据表明，微小RNA的改变参与癌症发展。微小RNA - 145在多种类型癌症中通常下调，通过靶向多个癌基因来调节各种细胞过程，如细胞周期、增殖、凋亡和侵袭。本综述旨在总结最近发表的关于微小RNA - 145在调节肿瘤发生和进展中的作用的文献，并探讨其在癌症诊断、预后和治疗方面的潜力。