Department of Urology, Hangzhou Mingzhou Hospital, Hangzhou, 311215, Zhe'jiang, China.
Department of the First Surgery, Zhejiang Provincial Corps Hospital of Chinese People's Armed Police Force, Hangzhou, 310051, Zhe'jiang, China.
Funct Integr Genomics. 2024 Aug 31;24(5):147. doi: 10.1007/s10142-024-01433-9.
Bladder cancer (BCa) is a highly prevalent type of cancer worldwide, and it is responsible for numerous deaths and cases of disease. Due to the diverse nature of this disease, it is necessary to conduct significant research that delves deeper into the molecular aspects, to potentially discover novel diagnostic and therapeutic approaches. Lately, there has been a significant increase in the focus on non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), due to their growing recognition for their involvement in the progression and manifestation of BCa. The interest in exosomes has greatly grown due to their potential for transporting a diverse array of active substances, including proteins, nucleic acids, carbohydrates, and lipids. The combination of these components differs based on the specific cell and its condition. Research indicates that using exosomes could have considerable advantages in identifying and forecasting BCa, offering a less invasive alternative. The distinctive arrangement of the lipid bilayer membrane found in exosomes is what makes them particularly effective for administering treatments aimed at managing cancer. In this review, we have tried to summarize different ncRNAs that are involved in BCa pathogenesis. Moreover, we highlighted the role of exosomal ncRNAs in BCa.
膀胱癌（BCa）是一种在全球范围内高发的癌症，它导致了大量的死亡和疾病病例。由于这种疾病的多样性，有必要进行深入的分子研究，以潜在地发现新的诊断和治疗方法。最近，由于非编码 RNA（ncRNAs），包括 microRNAs（miRNAs）、长非编码 RNA（lncRNAs）和环状 RNA（circRNAs）在 BCa 进展和表现中的作用越来越受到重视，因此对它们的研究也越来越多。由于外泌体能够运输多种活性物质，包括蛋白质、核酸、碳水化合物和脂质，因此它们的潜力引起了极大的关注。这些成分的组合根据特定的细胞及其状态而有所不同。研究表明，使用外泌体在识别和预测 BCa 方面具有相当大的优势，提供了一种侵入性更小的选择。外泌体中脂质双层膜的独特排列方式使它们特别适合用于管理癌症的治疗。在这篇综述中，我们试图总结了参与 BCa 发病机制的不同 ncRNAs。此外，我们还强调了外泌体 ncRNAs 在 BCa 中的作用。
