Alenina Natalia, Klempin Friederike
Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany.
Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany.
Behav Brain Res. 2015 Jan 15;277:49-57. doi: 10.1016/j.bbr.2014.07.038. Epub 2014 Aug 11.
Serotonin is probably best known for its role in conveying a sense of contentedness and happiness. It is one of the most unique and pharmacologically complex monoamines in both the peripheral and central nervous system (CNS). Serotonin has become in focus of interest for the treatment of depression with multiple serotonin-mimetic and modulators of adult neurogenesis used clinically. Here we will take a broad view of serotonin from development to its physiological role as a neurotransmitter and its contribution to homeostasis of the adult rodent hippocampus. This chapter reflects the most significant findings on cellular and molecular mechanisms from neuroscientists in the field over the last two decades. We illustrate the action of serotonin by highlighting basic receptor targeting studies, and how receptors impact brain function. We give an overview of recent genetically modified mouse models that differ in serotonin availability and focus on the role of the monoamine in antidepressant response. We conclude with a synthesis of the most recent data surrounding the role of serotonin in activity and hippocampal neurogenesis. This synopsis sheds light on the mechanisms and potential therapeutic model by which serotonin plays a critical role in the maintenance of mood.
血清素可能最为人所知的是它在传递满足感和幸福感方面的作用。它是外周和中枢神经系统（CNS）中最独特且药理学上最复杂的单胺之一。血清素已成为治疗抑郁症的关注焦点，临床上使用了多种血清素模拟物和成年神经发生调节剂。在这里，我们将从发育到其作为神经递质的生理作用以及对成年啮齿动物海马体稳态的贡献等方面，对血清素进行全面的审视。本章反映了该领域神经科学家在过去二十年中关于细胞和分子机制的最重要发现。我们通过突出基本的受体靶向研究以及受体如何影响脑功能来阐述血清素的作用。我们概述了近期在血清素可用性方面存在差异的基因改造小鼠模型，并重点关注单胺在抗抑郁反应中的作用。我们以围绕血清素在活动和海马体神经发生中的作用的最新数据综合作为结尾。这一综述揭示了血清素在维持情绪方面发挥关键作用的机制和潜在治疗模式。
