Bostancı Vildan, Toker Hulya, Senel Soner, Sahin Safak
Quintessence Int. 2014 Oct;45(9):743-8. doi: 10.3290/j.qi.a32442.
The aim of this study was to compare the periodontal status in patients with Familial Mediterranean Fever (FMF) and in those without this disease.
84 subjects clinically diagnosed with FMF and 75 systemically healthy controls, matched by age and gender, were recruited. All FMF patients were on a regular daily colchicine treatment and during attack-free periods. Gingival Index (GI), Plaque Index (PI), probing pocket depth (PD), and clinical attachment level (CAL) were measured in all subjects. To evaluate periodontal disease further, patients were stratified into fi ve groups. Education information and smoking habits were recorded.
The FMF patients and healthy controls were comparable for age, gender, and smoking status (P>.05). The FMF patients had significantly higher PI and GI values and lower PD and CAL values than those of the control group (P<.05). However, there was no significant difference among all groups in terms of periodontal disease severity (P>.05). In the FMF-severe periodontitis group, higher PI and GI values were seen (P<.05). However, there was no significant difference between the FMF-severe periodontitis group and the controls with severe periodontitis regarding the PD and CAL values (P>.05).
Patients with FMF using colchicine did not manifest higher attachment loss compared to age- and sex-matched systemically healthy controls.
本研究旨在比较家族性地中海热（FMF）患者与非该病患者的牙周状况。
招募了84例临床诊断为FMF的受试者和75例年龄及性别匹配的全身健康对照者。所有FMF患者均在无发作期接受每日规律的秋水仙碱治疗。对所有受试者测量牙龈指数（GI）、菌斑指数（PI）、探诊深度（PD）和临床附着水平（CAL）。为进一步评估牙周疾病，将患者分为五组。记录教育信息和吸烟习惯。
FMF患者与健康对照者在年龄、性别和吸烟状况方面具有可比性（P>0.05）。FMF患者的PI和GI值显著高于对照组，而PD和CAL值低于对照组（P<0.05）。然而，在牙周疾病严重程度方面，所有组之间无显著差异（P>0.05）。在FMF-重度牙周炎组中，观察到较高的PI和GI值（P<0.05）。然而，FMF-重度牙周炎组与重度牙周炎对照组在PD和CAL值方面无显著差异（P>0.05）。
与年龄和性别匹配的全身健康对照者相比，使用秋水仙碱的FMF患者未表现出更高的附着丧失。
