Department of Periodontology, Faculty of Dentistry, University of Süleyman Demirel, Isparta, Turkey.
Department of Internal Medicine, Division of Rheumatology, University of Süleyman Demirel.
J Periodontol. 2018 Apr;89(4):456-465. doi: 10.1002/JPER.17-0243. Epub 2018 Feb 27.
There are no published studies regarding the role of the plasminogen (PLG) system in familial Mediterranean fever (FMF), FMF-associated secondary amyloidosis, or chronic periodontitis (CP), although recent limited data have focused on the association between FMF and chronic periodontitis. Therefore, the aim of this study was to evaluate the serum, salivary, and gingival tissue levels of PLG in patients with CP, FMF, and amyloidosis.
The study population included 122 patients with FMF (only FMF, and FMF and amyloidosis and 128 individuals who were systemically healthy controls. Blood and salivary samples were obtained from the cases and controls, and clinical periodontal parameters were recorded. Serum and salivary PLG levels were assessed. The gingival tissue samples of the case and control groups were analyzed histopathologically and immunohistochemically for amyloid deposition and PLG.
The amyloidosis group had significantly more severe clinical periodontal parameters than those of the FMF and systemically healthy groups (P < 0.05). Salivary levels of PLG were significantly higher in the FMF and amyloidosis groups compared with those in the control group (P < 0.001). The FMF with periodontitis and amyloidosis with periodontitis groups had higher salivary PLG levels compared with those in the CP group. Serum and salivary PLG levels were significantly associated with the clinical periodontal parameters in the FMF group. The amyloidosis cases had hyperplasia, severe inflammation, and activation of the gingiva.
The PLG system could play an important role in inflammatory diseases, such as chronic periodontitis, FMF, and FMF-associated secondary amyloidosis.
目前尚无关于纤溶酶原（PLG）系统在家族性地中海热（FMF）、FMF 相关继发性淀粉样变性或慢性牙周炎（CP）中的作用的研究，尽管最近的有限数据集中在 FMF 和慢性牙周炎之间的关联。因此，本研究旨在评估 CP、FMF 和淀粉样变性患者的血清、唾液和牙龈组织中的 PLG 水平。
研究人群包括 122 名 FMF 患者（仅 FMF、FMF 和淀粉样变性）和 128 名系统性健康对照者。从病例和对照组中采集血液和唾液样本，并记录临床牙周参数。评估血清和唾液 PLG 水平。对病例和对照组的牙龈组织样本进行组织病理学和免疫组织化学分析，以评估淀粉样物质沉积和 PLG。
淀粉样变性组的临床牙周参数明显比 FMF 组和系统性健康组严重（P<0.05）。FMF 组和淀粉样变性组的唾液 PLG 水平明显高于对照组（P<0.001）。FMF 伴牙周炎和淀粉样变性伴牙周炎组的唾液 PLG 水平高于 CP 组。FMF 组的血清和唾液 PLG 水平与临床牙周参数显著相关。淀粉样变性病例的牙龈有增生、严重炎症和激活。
PLG 系统可能在慢性牙周炎、FMF 和 FMF 相关继发性淀粉样变性等炎症性疾病中发挥重要作用。
