性别及胸主动脉不同节段对生物活性主动脉物质（BAS）和前列环素（PGI2）合成的影响。

The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis.

作者信息

Maugeri N, Bermejo E, Faletti A, Schattner M A, Chaud M, Gimeno M F, Lazzari M A

机构信息

Department of Hemostasis and Thrombosis, Instituto de Investigaciones Hematologicas Mariano R. Castex, Buenos Aires, Argentina.

出版信息

Thromb Res. 1989 Oct 1;56(1):19-27. doi: 10.1016/0049-3848(89)90004-2.

DOI:10.1016/0049-3848(89)90004-2

PMID:2512685

Abstract

BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2. We evaluated three different segments of thoracic aorta: A = aortic arch, B = the upper segment and C = the lowest segment of the thoracic aorta. We measured the release of BAS and PGI2 from them. The BAS production increased in the first segment (A) when compared with the other two (B and C), whilst PGI2 production was the same along the thoracic aorta. On the other hand female and male thoracic aorta produced the same levels of BAS and 6-keto PGF1 cm.

摘要

BAS是从大鼠分离的主动脉环产生的一种蛋白质。我们之前的结果清楚地表明，BAS可抑制血小板聚集并改变血管张力。我们现在研究了胸主动脉不同节段的作用以及性别对BAS和前列环素（PGI2）释放的影响。我们评估了胸主动脉的三个不同节段：A = 主动脉弓，B = 胸主动脉上段，C = 胸主动脉最下段。我们测量了它们释放的BAS和PGI2。与其他两个节段（B和C）相比，第一节段（A）中BAS的产生增加，而沿胸主动脉PGI2的产生相同。另一方面，雌性和雄性胸主动脉产生的BAS和6-酮-前列腺素F1α水平相同。